Insulin-like Growth Factor (IGF)/IGF-1 Receptor (IGF-1R) signaling is known to regulate stem
cell pluripotency and differentiation to trigger cell proliferation, organ development, and …

Ghrelin widely exists in the central nervous system and peripheral organs, and has
biological activities such as maintaining energy homeostasis, regulating lipid metabolism …

Simple Summary Uveal melanoma (UM) is the most common eye cancer in adults and its
spreading to the liver has poor outcomes for the patients. There is currently only one …

Background Binding of insulin-like growth factor-I (IGF-1) to its receptor (IGF-1R) initiates
downstream signals that activate PI3K/Akt/mTOR and MEK/Erk pathways, which stimulate …

This review provides epidemiological and translational evidence for milk and dairy intake as
critical risk factors in the pathogenesis of hepatocellular carcinoma (HCC). Large …

The systemic therapy landscape for hepatocellular carcinoma is rapidly evolving, as the
recent approvals of checkpoint inhibitor-based regimens such as atezolizumab …

Insulin growth factor (IGF) family and their receptors play a great role in tumors'
development. In addition, IGF-1 enhances cancer progression through regulating cell …

Objective: The purpose of this study was to reduce the time to tumor onset in a
diethylnitrosamine (DEN)-induced hepatocellular carcinoma (HCC) swine model via partial …

Abstract Purpose of Review Interventional oncology (IO) loco-regional treatments are widely
utilized in clinical practice. However, local tumor control rates are still widely variable. There …

Purpose Child-Turcotte-Pugh class A (CTP-A) in unresectable hepatocellular carcinoma
(HCC) is the standard criterion for active therapy and clinical trial enrollment. We …