A guide to the organ-on-a-chip

CM Leung, P De Haan… - Nature Reviews …, 2022 - nature.com
Abstract Organs-on-chips (OoCs) are systems containing engineered or natural miniature
tissues grown inside microfluidic chips. To better mimic human physiology, the chips are …

Human organs-on-chips for disease modelling, drug development and personalized medicine

DE Ingber - Nature Reviews Genetics, 2022 - nature.com
The failure of animal models to predict therapeutic responses in humans is a major problem
that also brings into question their use for basic research. Organ-on-a-chip (organ chip) …

Organ-on-a-chip: Recent breakthroughs and future prospects

Q Wu, J Liu, X Wang, L Feng, J Wu, X Zhu… - Biomedical engineering …, 2020 - Springer
The organ-on-a-chip (OOAC) is in the list of top 10 emerging technologies and refers to a
physiological organ biomimetic system built on a microfluidic chip. Through a combination of …

Advances in organ-on-a-chip engineering

B Zhang, A Korolj, BFL Lai, M Radisic - Nature Reviews Materials, 2018 - nature.com
Predicting the effects of drugs before human clinical trials is at the heart of drug screening
and discovery processes. The cost of drug discovery is steadily increasing owing to the …

Biomimetic human disease model of SARS‐CoV‐2‐induced lung injury and immune responses on organ chip system

M Zhang, P Wang, R Luo, Y Wang, Z Li… - Advanced …, 2021 - Wiley Online Library
Abstract Coronavirus disease 2019 (COVID‐19) is a global pandemic caused by severe
acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2). The models that can accurately …

Organs-on-a-chip: a fast track for engineered human tissues in drug development

K Ronaldson-Bouchard, G Vunjak-Novakovic - Cell stem cell, 2018 - cell.com
Organs-on-a-chip (OOCs) are miniature tissues and organs grown in vitro that enable
modeling of human physiology and disease. The technology has emerged from converging …

Evolution of biochip technology: A review from lab-on-a-chip to organ-on-a-chip

N Azizipour, R Avazpour, DH Rosenzweig, M Sawan… - Micromachines, 2020 - mdpi.com
Following the advancements in microfluidics and lab-on-a-chip (LOC) technologies, a novel
biomedical application for microfluidic based devices has emerged in recent years and …

Interconnected microphysiological systems for quantitative biology and pharmacology studies

CD Edington, WLK Chen, E Geishecker, T Kassis… - Scientific reports, 2018 - nature.com
Microphysiological systems (MPSs) are in vitro models that capture facets of in vivo organ
function through use of specialized culture microenvironments, including 3D matrices and …

Microfluidic organs-on-chips

SN Bhatia, DE Ingber - Nature biotechnology, 2014 - nature.com
An organ-on-a-chip is a microfluidic cell culture device created with microchip manufacturing
methods that contains continuously perfused chambers inhabited by living cells arranged to …

High-throughput methods in the discovery and study of biomaterials and materiobiology

L Yang, S Pijuan-Galito, HS Rho, AS Vasilevich… - Chemical …, 2021 - ACS Publications
The complex interaction of cells with biomaterials (ie, materiobiology) plays an increasingly
pivotal role in the development of novel implants, biomedical devices, and tissue …