Evidence accumulated that mesenchymal stem cell (MSC) therapy ameliorated osteoarthritis
(OA) via paracrine effect, whereas conditioned medium (CM) of MSCs contains all the …

Objective Abnormal load stress caused by joint instability has been reported to be one of the
factors responsible for the development of osteoarthritis (OA). However, few studies have …

Methods: The detailed protocol for this study was published in the International Prospective
Register of Systematic Reviews in the field of health and social welfare (CRD …

Objective It has been debated whether the onset of knee osteoarthritis is initiated in cartilage
or subchondral bone. The purpose of this study was to clarify the effects of increasing or …

Subjects with developmental dysplasia of the hip (DDH) often show early-onset
osteoarthritis (OA); however, the molecular mechanisms underlying this pathology are not …

To identify the effects of running on articular cartilage and subchondral bone remodeling,
C57BL/6 mice were randomly divided into three groups: control, moderate‐, and strenuous …

AMD3100 is a small-molecule inhibitor of the CXC motif chemokine ligand 12/CXC
chemokine receptor type 4 (CXCL12/CXCR4) axis, while its role in aggrecan metabolism is …

Objective Moderate mechanical stress is necessary for preserving the cartilage. The
clinician empirically understands that prescribing only exercise will progress osteoarthritis …

Nanotechnology holds substantial promise in the innovative therapies for rheumatoid
arthritis (RA). The current study was designed to synthesize and characterize a new …

Cartilage extracellular matrix (ECM) metabolism disorder caused by mechanical instability is
a leading cause of osteoarthritis (OA), but the exact mechanisms have not been fully …