The Notch pathway is prominent among those known to regulate neural development in
vertebrates. Notch receptor activation can inhibit neurogenesis, maintain neural progenitor …

Musashi is an evolutionarily conserved family of RNA-binding proteins that is preferentially
expressed in the nervous system. The first member of the Musashi family was identified in …

The basic helix-loop-helix transcription factors Ascl1/Mash1, Hes1, and Olig2 regulate fate
choice of neurons, astrocytes, and oligodendrocytes, respectively. These same factors are …

The hope of developing new transplantation therapies for degenerative diseases is limited
by inefficient stem cell growth and immunological incompatibility with the host,. Here we …

During brain development, neurons and glia are generated from a germinal zone containing
both neural stem cells (NSCs) and more limited intermediate neural progenitors (INPs),,. The …

During midgestation, mammalian neural precursor cells (NPCs) differentiate only into
neurons. Generation of astrocytes is prevented at this stage, because astrocyte-specific …

The different cell types in the central nervous system develop from a common pool of
progenitor cells. The nuclei of progenitors move between the apical and basal surfaces of …

The Wnt and Notch signalling pathways represent two major channels of communication
used by animal cells to control their identities and behaviour during development. A number …

The mammalian neocortex is established from neural stem and progenitor cells that utilize
specific transcriptional and environmental factors to create functional neurons and …

The Notch signaling pathway is central to a wide array of developmental processes in a
number of organ systems, including hematopoiesis, somitogenesis, vasculogenesis, and …