Cell migration is essential for physiological processes as diverse as development, immune
defence and wound healing. It is also a hallmark of cancer malignancy. Thousands of …

The cytoskeleton of animal cells is one of the most complicated and functionally versatile
structures, involved in processes such as endocytosis, cell division, intra-cellular transport …

Precisely controlled cell deformations are key to cell migration, division and tissue
morphogenesis, and have been implicated in cell differentiation during development, as well …

Mechanosensitive ion channels are force-transducing enzymes that couple mechanical
stimuli to ion flux. Understanding the gating mechanism of mechanosensitive channels is …

Blebs are cellular protrusions that have been shown to be instrumental for cell migration in
development and disease. Bleb expansion is driven by hydrostatic pressure generated in …

Cells migrating on flat two-dimensional (2D) surfaces use actin polymerization to extend the
leading edge of the plasma membrane during lamellipodia-based migration. This mode of …

Cell migration results from stepwise mechanical and chemical interactions between cells
and their extracellular environment. Mechanistic principles that determine single-cell and …

The actin motor protein non-muscle myosin II (NMII) acts as a master regulator of cell
morphology, with a role in several essential cellular processes, including cell migration and …

In the context of development, tissue homeostasis, immune surveillance, and pathological
conditions such as cancer metastasis and inflammation, migrating amoeboid cells …

Bleb-based migration, a conserved cell motility mode, has a crucial role in both
physiological and pathological processes. Unlike the well-elucidated mechanisms of …