Advanced glycation end products (AGEs) are potentially harmful and heterogeneous
molecules derived from nonenzymatic glycation. The pathological implications of AGEs are …

Adolescence is a developmental period when physical and cognitive abilities are optimized,
when social skills are consolidated, and when sexuality, adolescent behaviors, and frontal …

Suicide is a major medical and social problem. Decades of suicide research have mostly
focused on risk factors for suicidal behaviour while overlooking protective factors such as …

Alcohol consumption and stress increase brain levels of known innate immune signaling
molecules. Microglia, the innate immune cells of the brain, and neurons respond to alcohol …

Objective: Heavy alcohol use during adolescence may alter the trajectory of normal brain
development. The authors measured within-subject changes in regional brain morphometry …

Rationale Alcoholism is a primary, chronic relapsing disease of brain reward, motivation,
memory, and related circuitry. It is characterized by an individual's continued drinking …

The innate immune response in the central nervous system (CNS) participates in both
synaptic plasticity and neural damage. Emerging evidence from human and animal studies …

Induction of neuroimmune genes by binge drinking increases neuronal excitability and
oxidative stress, contributing to the neurobiology of alcohol dependence and causing …

Abstract Background Athina Markou and her colleagues discovered persistent changes in
adult behavior following adolescent exposure to ethanol or nicotine consistent with …

Adolescence is a developmental period that coincides with the maturation of adult cognitive
faculties. Binge drinking is common during adolescence and can impact brain maturation …