The potential role of ischaemia–reperfusion injury in chronic, relapsing diseases such as rheumatoid arthritis, Long COVID, and ME/CFS: evidence, mechanisms, and …

DB Kell, E Pretorius - Biochemical Journal, 2022 - portlandpress.com
Ischaemia–reperfusion (I–R) injury, initiated via bursts of reactive oxygen species produced
during the reoxygenation phase following hypoxia, is well known in a variety of acute …

Sepsis-associated brain injury: underlying mechanisms and potential therapeutic strategies for acute and long-term cognitive impairments

N Sekino, M Selim, A Shehadah - Journal of Neuroinflammation, 2022 - Springer
Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to
infection. Sepsis causes cerebral dysfunction in the short and long term and induces …

Sepsis promotes splenic production of a protective platelet pool with high CD40 ligand expression

C Valet, M Magnen, L Qiu, SJ Cleary… - The Journal of …, 2022 - Am Soc Clin Investig
Platelets have a wide range of functions including critical roles in hemostasis, thrombosis,
and immunity. We hypothesized that during acute inflammation, such as in life-threatening …

During sepsis and COVID-19, the pro-inflammatory and anti-inflammatory responses are concomitant

JM Cavaillon - Clinical Reviews in Allergy & Immunology, 2023 - Springer
The most severe forms of COVID-19 share many features with bacterial sepsis and have
thus been considered to be a viral sepsis. Innate immunity and inflammation are closely …

Tissue-specific reprogramming of glutamine metabolism maintains tolerance to sepsis

BP Leitner, WD Lee, W Zhu, X Zhang, RC Gaspar… - PLoS …, 2023 - journals.plos.org
Reprogramming metabolism is of great therapeutic interest for reducing morbidity and
mortality during sepsis-induced critical illness. Disappointing results from randomized …

Neurological complications of sepsis

S Piva, M Bertoni, N Gitti, FA Rasulo… - Current Opinion in …, 2023 - journals.lww.com
Neurological complications of sepsis : Current Opinion in Critical Care Neurological
complications of sepsis : Current Opinion in Critical Care Log in or Register Subscribe to …

Superantigens promote Staphylococcus aureus bloodstream infection by eliciting pathogenic interferon-gamma production

SW Tuffs, MI Goncheva, SX Xu… - Proceedings of the …, 2022 - National Acad Sciences
Staphylococcus aureus is a foremost bacterial pathogen responsible for a vast array of
human diseases. Staphylococcal superantigens (SAgs) constitute a family of exotoxins from …

Understanding post-sepsis syndrome: how can clinicians help?

EC Van der Slikke, LFE Beumeler… - Infection and Drug …, 2023 - Taylor & Francis
Sepsis is a global health challenge, with over 49 million cases annually. Recent medical
advancements have increased in-hospital survival rates to approximately 80%, but the …

Polarization of microglia and its therapeutic potential in sepsis

LVG Castro, CF Gonçalves-de-Albuquerque… - International Journal of …, 2022 - mdpi.com
Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to
infection, leaving the inflammation process without a proper resolution, leading to tissue …

Systemic inflammation induced the delayed reduction of excitatory synapses in the CA3 during ageing

T Manabe, I Rácz, S Schwartz, L Oberle… - Journal of …, 2021 - Wiley Online Library
Sepsis‐associated encephalopathy (SAE) represents diverse cerebral dysfunctions in
response to pathogen‐induced systemic inflammation. Peripheral exposure to …