Understanding of molecular mechanisms of tumor growth has an increasing impact on the
development of diagnostics and targeted therapy of human neoplasia. In this review, we …

The epididymis consists of a single, highly coiled and convoluted tubule that Antoine De
Graaf, the famous 17th‐century anatomist, likened to a thread thickening to a string. The …

Throughout embryonic and early postnatal development, the mammalian epididymis
changes from a straight tube to a highly coiled, complex duct that links the efferent ducts to …

Introduction Hemangioblastomas are rare, histologically benign, highly vascularized tumors
of the brain, the spinal cord, and the retina, occurring sporadically or associated with the …

Background The primary cilium is a microtubule‐based organelle that extends transiently
from the apical cell surface to act as a sensory antenna. Initially viewed as a cellular …

von Hippel-Lindau (VHL) disease is an autosomal-dominant familial cancer syndrome
associated with mutations of the VHL tumor suppressor gene (3p25-26). Its estimated …

Abstract Patients with von Hippel–Lindau disease carry a germline mutation of the Von
Hippel–Lindau (VHL) tumor-suppressor gene. We discuss the molecular consequences of …

Spermatozoa undergo a posttesticular maturation in the epididymis to acquire motility and
the capacity to fertilize. Sperm maturation depends in part upon the creation of a specific …

Papillary cystadenoma is a rare benign neoplasm of the epididymis, occurring mainly in
young adult males. More than one-third of the cases reported in the literature have occurred …

Methods Nontumoral pancreas of 18 VHL patients operated on for PET, was examined for
microadenomatosis (≤ 5 mm) and compared with pancreatic specimen obtained from non …