Muscular exercise requires transitions to and from metabolic rates often exceeding an order
of magnitude above resting and places prodigious demands on the oxidative machinery and …

The activities of daily living typically occur at metabolic rates below the maximum rate of
aerobic energy production. Such activity is characteristic of the nonsteady state, where …

Evidence has emerged that the failing heart increases utilization of ketone bodies. We
sought to determine whether this fuel shift is adaptive. Mice rendered incapable of oxidizing …

Calcium is believed to regulate mitochondrial oxidative phosphorylation, thereby
contributing to the maintenance of cellular energy homeostasis. Skeletal muscle, with an …

Even-chain acylcarnitine (AC) metabolites, most of which are generated as byproducts of
incomplete fatty acid oxidation (FAO), are viewed as biomarkers of mitochondrial lipid stress …

Chronic metabolic diseases have been linked to molecular signatures of mitochondrial
dysfunction. Nonetheless, molecular remodeling of the transcriptome, proteome, and/or …

The early time course of adaptation of pulmonary O2 uptake (V̇o2p)(reflecting muscle O2
consumption) and muscle deoxygenation kinetics (reflecting the rate of O2 extraction) were …

Magnetic resonance spectroscopy (MRS) can give information about cellular metabolism in
vivo which is difficult to obtain in other ways. In skeletal muscle, non‐invasive 31 P MRS …

Chronic kidney disease (CKD) leads to increased skeletal muscle fatigue, weakness, and
atrophy. Previous work has implicated mitochondria within the skeletal muscle as a mediator …

This study sought to examine the functional significance of mitochondrial protein acetylation
using a double knockout (DKO) mouse model harboring muscle-specific deficits in acetyl …