Immune-mediated inflammatory diseases (IMIDs) are characterized by excessive and
uncontrolled inflammation and thrombosis, both of which are responsible for organ damage …

Despite its position as the first-line drug for treatment of type 2 diabetes mellitus, the
mechanisms underlying the plasma glucose level-lowering effects of metformin (1, 1 …

The success of immunotherapy in oncology underscores the vital role of the immune system
in cancer development. Regulatory T cells (Tregs) maintain a fine balance between …

Multiple sclerosis (MS) is more common in western countries with diet being a potential
contributing factor. Here we show that intermittent fasting (IF) ameliorated clinical course and …

Leptin, an adipokine that is implicated in the control of food intake via appetite suppression,
may also stimulate oxidative stress, inflammation, thrombosis, arterial stiffness …

Despite the large number of immunomodulatory or immunosuppressive treatments available
to treat relapsing–remitting multiple sclerosis (MS), treatment of the progressive phase of the …

Metformin is a lipophilic biguanide which inhibits hepatic gluconeogenesis and improves
peripheral utilization of glucose. It is the first line pharmacotherapy for glucose control in …

Metformin is everywhere. Originally introduced in clinical practice as an antidiabetic agent,
its role as a therapeutic agent is expanding to include treatment of prediabetes mellitus …

Augmented T cell function leading to host damage in autoimmunity is supported by
metabolic dysregulation, making targeting immunometabolism an attractive therapeutic …

The rapidly evolving therapeutic landscape of multiple sclerosis (MS) has contributed to
paradigm shifts in our understanding of the biological mechanisms that contribute to CNS …