Rhabdomyosarcoma
SX Skapek, A Ferrari, AA Gupta, PJ Lupo… - Nature reviews disease …, 2019 - nature.com
Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in children and
represents a high-grade neoplasm of skeletal myoblast-like cells. Decades of clinical and …
represents a high-grade neoplasm of skeletal myoblast-like cells. Decades of clinical and …
Aneuploidy and complex genomic rearrangements in cancer evolution
TM Baker, S Waise, M Tarabichi, P Van Loo - Nature cancer, 2024 - nature.com
Mutational processes that alter large genomic regions occur frequently in developing
tumors. They range from simple copy number gains and losses to the shattering and …
tumors. They range from simple copy number gains and losses to the shattering and …
Comprehensive genomic analysis of rhabdomyosarcoma reveals a landscape of alterations affecting a common genetic axis in fusion-positive and fusion-negative …
Despite gains in survival, outcomes for patients with metastatic or recurrent
rhabdomyosarcoma remain dismal. In a collaboration between the National Cancer Institute …
rhabdomyosarcoma remain dismal. In a collaboration between the National Cancer Institute …
PAX3–FOXO1 establishes myogenic super enhancers and confers BET bromodomain vulnerability
Alveolar rhabdomyosarcoma is a life-threatening myogenic cancer of children and
adolescent young adults, driven primarily by the chimeric transcription factor PAX3–FOXO1 …
adolescent young adults, driven primarily by the chimeric transcription factor PAX3–FOXO1 …
Fibroblast growth factors and their receptors in cancer
J Wesche, K Haglund, EM Haugsten - Biochemical Journal, 2011 - portlandpress.com
FGFs (fibroblast growth factors) and their receptors (FGFRs) play essential roles in tightly
regulating cell proliferation, survival, migration and differentiation during development and …
regulating cell proliferation, survival, migration and differentiation during development and …
The impact of translocations and gene fusions on cancer causation
F Mitelman, B Johansson, F Mertens - Nature Reviews Cancer, 2007 - nature.com
Chromosome aberrations, in particular translocations and their corresponding gene fusions,
have an important role in the initial steps of tumorigenesis; at present, 358 gene fusions …
have an important role in the initial steps of tumorigenesis; at present, 358 gene fusions …
Classification of rhabdomyosarcoma and its molecular basis
DM Parham, FG Barr - Advances in anatomic pathology, 2013 - journals.lww.com
Rhabdomyosarcoma (RMS), the most common soft tissue sarcoma in children, has
traditionally been classified into embryonal rhabdomyosarcoma (ERMS) and alveolar …
traditionally been classified into embryonal rhabdomyosarcoma (ERMS) and alveolar …
An update on rhabdomyosarcoma risk stratification and the rationale for current and future Children's Oncology Group clinical trials
JH Haduong, CM Heske… - Pediatric blood & …, 2022 - Wiley Online Library
Children and adolescents with rhabdomyosarcoma (RMS) comprise a heterogeneous
population with variable overall survival rates ranging between approximately 6% and 100 …
population with variable overall survival rates ranging between approximately 6% and 100 …
Trends in childhood rhabdomyosarcoma incidence and survival in the United States, 1975‐2005
S Ognjanovic, AM Linabery… - … Journal of the …, 2009 - Wiley Online Library
BACKGROUND: Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in
children and adolescents aged< 20 years; its etiology remains largely unknown. It is …
children and adolescents aged< 20 years; its etiology remains largely unknown. It is …
Single-cell profiling of alveolar rhabdomyosarcoma reveals RAS pathway inhibitors as cell-fate hijackers with therapeutic relevance
Rhabdomyosarcoma (RMS) is a group of pediatric cancers with features of developing
skeletal muscle. The cellular hierarchy and mechanisms leading to developmental arrest …
skeletal muscle. The cellular hierarchy and mechanisms leading to developmental arrest …