Besides the broad development of nanotechnological approaches for cancer diagnosis and
therapy, currently, there is no significant progress in the treatment of different types of brain …

The blood brain barrier (BBB) presents a formidable challenge to the delivery of drugs into
the brain. Several strategies aim to overcome this obstacle and promote efficient and …

Obtaining efficient drug delivery to the brain remains the biggest challenge for the
development of therapeutics to treat diseases of the central nervous system. The main …

Iron is an essential element for virtually all organisms. On the one hand, it facilitates cell
proliferation and growth. On the other hand, iron may be detrimental due to its redox …

Engineered nanoparticles offer the chance to improve drug transport and delivery through
biological barriers, exploiting the possibility to leave the blood circulation and traverse the …

High-grade glioma is one of the most aggressive types of cancer with a low survival rate
ranging from 12 to 15 months after the first diagnosis. Though being the most common …

Brain drug delivery may be restricted by the blood-brain barrier (BBB), and enhancement by
liposome-based drug delivery strategies has been investigated. As access to the human …

Rationale: The ability to treat invalidating neurological diseases is impeded by the presence
of the blood-brain barrier (BBB), which inhibits the transport of most blood-borne substances …

Drug encapsulated liposomes and monoclonal antibodies (Mabs) are two distinctively
different classes of therapeutics, but both aim to become the ultimate “magic bullet”. While …

The existence of the blood–brain barrier (BBB) makes the clinical chemotherapy of glioma a
formidable challenge, because it hinders the passage of different chemotherapeutics into …