[HTML][HTML] Noradrenergic and cholinergic systems take centre stage in neuropsychiatric diseases of ageing
Noradrenergic and cholinergic systems are among the most vulnerable brain systems in
neuropsychiatric diseases of ageing, including Alzheimer's disease, Parkinson's disease …
neuropsychiatric diseases of ageing, including Alzheimer's disease, Parkinson's disease …
State-of-the-art imaging of neuromodulatory subcortical systems in aging and Alzheimer's disease: Challenges and opportunities
N Engels-Domínguez, EA Koops, PC Prokopiou… - Neuroscience & …, 2023 - Elsevier
Primary prevention trials have shifted their focus to the earliest stages of Alzheimer's disease
(AD). Autopsy data indicates that the neuromodulatory subcortical systems'(NSS) nuclei are …
(AD). Autopsy data indicates that the neuromodulatory subcortical systems'(NSS) nuclei are …
[HTML][HTML] Noradrenaline in alzheimer's disease: A new potential therapeutic target
A growing body of evidence demonstrates the important role of the noradrenergic system in
the pathogenesis of many neurodegenerative processes, especially Alzheimer's disease …
the pathogenesis of many neurodegenerative processes, especially Alzheimer's disease …
The neurotoxin DSP-4 dysregulates the locus coeruleus-norepinephrine system and recapitulates molecular and behavioral aspects of prodromal neurodegenerative …
The noradrenergic locus coeruleus (LC) is among the earliest sites of tau and α-synuclein
pathology in Alzheimer's disease (AD) and Parkinson's disease (PD), respectively. The …
pathology in Alzheimer's disease (AD) and Parkinson's disease (PD), respectively. The …
Age-dependent dysregulation of locus coeruleus firing in a transgenic rat model of Alzheimer's disease
MA Kelberman, JM Rorabaugh, CR Anderson… - Neurobiology of …, 2023 - Elsevier
Hyperphosphorylated tau in the locus coeruleus (LC) is ubiquitous in prodromal Alzheimer's
disease (AD), and LC neurons degenerate as AD progresses. Hyperphosphorylated tau …
disease (AD), and LC neurons degenerate as AD progresses. Hyperphosphorylated tau …
[HTML][HTML] Locus coeruleus activity while awake is associated with REM sleep quality in older individuals
E Koshmanova, A Berger, E Beckers, I Campbell… - JCI insight, 2023 - ncbi.nlm.nih.gov
BACKGROUND The locus coeruleus (LC) is the primary source of norepinephrine in the
brain and regulates arousal and sleep. Animal research shows that it plays important roles …
brain and regulates arousal and sleep. Animal research shows that it plays important roles …
Altered structural covariance of locus coeruleus in individuals with significant memory concern and patients with mild cognitive impairment
Y Tang, M Cao, Y Li, Y Lin, X Wu, M Chen… - Cerebral …, 2023 - academic.oup.com
The locus coeruleus (LC) is the site where tau accumulation is preferentially observed
pathologically in Alzheimer's disease (AD) patients, but the changes in gray matter co …
pathologically in Alzheimer's disease (AD) patients, but the changes in gray matter co …
[HTML][HTML] Exploring the role of Locus Coeruleus in Alzheimer's Disease: a Comprehensive Update on MRI studies and implications
Abstract Purpose of Review Performing a thorough review of magnetic resonance imaging
(MRI) studies assessing locus coeruleus (LC) integrity in ageing and Alzheimer's disease …
(MRI) studies assessing locus coeruleus (LC) integrity in ageing and Alzheimer's disease …
[HTML][HTML] Age-related differences in the functional topography of the locus coeruleus and their implications for cognitive and affective functions
The locus coeruleus (LC) is an important noradrenergic nucleus that has recently attracted a
lot of attention because of its emerging role in cognitive and psychiatric disorders. Although …
lot of attention because of its emerging role in cognitive and psychiatric disorders. Although …
Cognitive impairment in alzheimer's and metabolic diseases: a catecholaminergic hypothesis
K Guzmán-Ramos, D Osorio-Gómez… - Neuroscience, 2022 - Elsevier
Catecholaminergic transmission plays an essential role in both physiological and
pathological cognitive functions. Plastic changes subserving learning and memory …
pathological cognitive functions. Plastic changes subserving learning and memory …