Mutations in the TP53 tumour suppressor gene are found in~ 50% of human cancers [,,,,–].
TP53 functions as a transcription factor that directly regulates the expression of~ 500 genes …

Mutant p53 proteins impart changes in cellular behavior and function through interactions
with proteins that alter gene expression. The milieu of intracellular proteins available to …

There is now strong evidence that mutation not only abrogates p53 tumor-suppressive
functions, but in some instances can also endow mutant proteins with novel activities. Such …

Somatic mutations in the TP53 gene are one of the most frequent alterations in human
cancers, and germline mutations are the underlying cause of Li-Fraumeni syndrome, which …

Compared with many normal tissues, cancer cells are highly sensitized to apoptotic signals,
and survive only because they have acquired lesions—such as loss of p53—that prevent or …

In its wild-type form, p53 is a major tumor suppressor whose function is critical for protection
against cancer. Many human tumors carry missense mutations in the TP53 gene, encoding …

The p53 pathway responds to stresses that can disrupt the fidelity of DNA replication and
cell division. A stress signal is transmitted to the p53 protein by post-translational …

The p53 tumor suppressor gene is commonly altered in human tumors, predominantly
through missense mutations that result in accumulation of mutant p53 protein. These …

A large amount of data is available on the functional impact of missense mutations in TP53
and on mutation patterns in many different cancers. New data on mutant p53 protein …

The gene TP53, encoding p53, has a common sequence polymorphism that results in either
proline or arginine at amino-acid position 72. This polymorphism occurs in the proline-rich …