[HTML][HTML] Challenges of Multidrug-Resistant Tuberculosis Meningitis: Current Treatments and the Role of Glutathione as an Adjunct Therapy

MJ Nasiri, K Lutfy, V Venketaraman - Vaccines, 2024 - mdpi.com
Multidrug-resistant tuberculosis (MDR-TB) poses a significant global health threat,
especially when it involves the central nervous system (CNS). Tuberculous meningitis …

Host-directed therapy against mycobacterium tuberculosis infections with diabetes mellitus

L Zhao, K Fan, X Sun, W Li, F Qin, L Shi, F Gao… - Frontiers in …, 2024 - frontiersin.org
Tuberculosis (TB) is caused by the bacterial pathogen Mycobacterium tuberculosis (MTB)
and is one of the principal reasons for mortality and morbidity worldwide. Currently …

Topical Absorption of Glutathione–Cyclodextrin Nanoparticle Complex in Healthy Human Subjects Improves Immune Response against Mycobacterium avium …

K Sasaninia, M Kelley, A Abnousian, A Badaoui… - Antioxidants, 2023 - mdpi.com
Glutathione (GSH) is an important intracellular antioxidant responsible for neutralizing
reactive oxygen species (ROS). Our laboratory previously demonstrated that the oral …

[HTML][HTML] Liposomal glutathione supplementation mitigates extrapulmonary tuberculosis in the liver and spleen

K Sasaninia, M Kelley, A Abnousian… - Frontiers in Bioscience …, 2023 - imrpress.com
Background: Extrapulmonary tuberculosis (EPTB) accounts for a fifth of all Mycobacterium
tuberculosis (M. tb) infections worldwide. The rise of multidrug resistance in M. tb alongside …

Comparative study of subcutaneous, intramuscular, and oral administration of bovine pathogenic Escherichia coli bacterial ghost vaccine in mice

J Mu, L Lei, Y Zheng, D Li, J Li, Y Fu, G Wang… - Frontiers in …, 2022 - frontiersin.org
Escherichia coli is one of the most common bacterial pathogens in cattle. Prophylactic
vaccines are considered promising strategies with the potential to reduce the incidence of …

[HTML][HTML] The Role of mTOR in Mycobacterium tuberculosis Infection

A Patel, L Nguyen, C Shea, S Singh, V Venketaraman - Biomedicines, 2024 - mdpi.com
Background/Objectives: Mycobacterium tuberculosis (M. tb) is a pathogen that causes
tuberculosis (TB), an extremely infectious disease which is responsible for millions of deaths …

Redox biomarkers in asymptomatic latent human tuberculosis: a comparison with active disease

S Petrillo, RR Di Prinzio, A Quatrana… - The Journal of …, 2024 - academic.oup.com
Background Latent tuberculosis infection is an asymptomatic infection caused by
Mycobacterium tuberculosis. Previous studies have shown a host-protective role for heme …

Resistance and Susceptibility Immune Factors at Play during Mycobacterium tuberculosis Infection of Macrophages

JD Simper, E Perez, LS Schlesinger, AK Azad - Pathogens, 2022 - mdpi.com
Tuberculosis (TB), caused by infection with Mycobacterium tuberculosis (M. tb), is
responsible for> 1.5 million deaths worldwide annually. Innate immune cells, especially …

Immunopathology of Pulmonary Mycobacterium tuberculosis Infection in a Humanized Mouse Model

A Kolloli, R Kumar, V Venketaraman… - International journal of …, 2024 - mdpi.com
Despite the availability of antibiotic therapy, tuberculosis (TB) is prevailing as a leading killer
among human infectious diseases, which highlights the need for better intervention …

Liposomal Glutathione Augments Immune Defenses against Respiratory Syncytial Virus in Neonatal Mice Exposed in Utero to Ethanol

TW Gauthier, XD Ping, FL Harris, LAS Brown - Antioxidants, 2024 - mdpi.com
We previously reported that maternal alcohol use increased the risk of sepsis in premature
and term newborns. In the neonatal mouse, fetal ethanol (ETOH) exposure depleted the …