Natural compounds have significant anticancer pharmacological activities, but often suffer
from low bioavailability and selectivity that limit therapeutic use. The present work critically …

The establishment of in vitro models of the BBB is significant for the evaluation of the
mechanism and permeability of drugs and their sustained-release formulations across the …

Adenosine triphosphate (ATP)-binding cassette (ABC) transporters are highly expressed in
tumor cells, as well as in organs involved in absorption and secretion processes, mediating …

The blood-brain barrier (BBB) serves to protect and regulate the CNS microenvironment.
The development of an in-vitro mimic of the BBB requires recapitulating the correct …

Breast cancer is one of the most common causes of mortality in women. Flavonoids, among
other compounds, are bioactive constituents of propolis. In this comparative study, we …

Malignant tumors remain one of the main sources of morbidity and mortality around the
world. A chemotherapeutic approach to cancer treatment poses a multitude of challenges …

The aryl hydrocarbon receptor (AhR) is a transcription factor deeply implicated in health and
diseases. Historically identified as a sensor of xenobiotics and mainly toxic substances, AhR …

The aryl hydrocarbon receptor (AhR) is a pleiotropic nuclear factor that was originally
recognized as a “master” of xenobiotic metabolism but demonstrated recently to be a vital …

Hyperglycemia alters the function of cerebral endothelial cells from the blood-brain barrier,
increasing the risk of cerebrovascular complications during diabetes. This study evaluated …

Unsubstituted flavone induced CYP1A1, CYP1B1 and UGT1A1 gene expression in Caco2
cells and was characterized as an aryl hydrocarbon receptor (AhR) agonist. The structure …