Classical biochemistry is founded on several assumptions valid in dilute aqueous solutions
that are often extended without question to the interior milieu of intact cells. In the first section …

The Golgi apparatus lies at the centre of the secretory pathway. It consists of a series of
flattened compartments typically organised into a stack that, in mammals, is connected to …

A large body of evidence indicates that microtubules (MTs) conduct organelle transport in
axons, but recent studies on extruded squid axoplasm have suggested that actin …

To establish laser-tracking microrheology (LTM) as a new technique for quantifying
cytoskeletal mechanics, we measure viscoelastic moduli with wide bandwidth (5 decades) …

We have discovered several novel features exhibited by microtubules (MTs) in migrating
newt lung epithelial cells by time-lapse imaging of fluorescently labeled, microinjected …

Fluorescence recovery after photobleaching (FRAP) was used to quantify the translational
diffusion of microinjected FITC-dextrans and Ficolls in the cytoplasm and nucleus of MDCK …

Distinct molecules are segregated into somatodendritic and axonal compartments of
polarized neurons, but mechanisms underlying the development and maintenance of such …

We develop a multiple particle tracking technique for making precise, localized
measurements of the mechanical microenvironments of inhomogeneous materials. Using …

Tubulin dimers assemble into dynamic microtubules, which are used by molecular motors as
tracks for intracellular transport. Organization and dynamics of the microtubule network are …

Reports on the ultrastructure of cells as well as biochemical data have, for several years,
been indicating a connection between caveolae and the actin cytoskeleton. Here, using a …