Ultrafast magic angle spinning solid-state NMR spectroscopy: Advances in methodology and applications

Y Nishiyama, G Hou, V Agarwal, Y Su… - Chemical …, 2022 - ACS Publications
Solid-state NMR spectroscopy is one of the most commonly used techniques to study the
atomic-resolution structure and dynamics of various chemical, biological, material, and …

[HTML][HTML] Solid-state NMR spectroscopy in pharmaceutical sciences

M Li, W Xu, Y Su - TrAC Trends in Analytical Chemistry, 2021 - Elsevier
Solid-state NMR (ssNMR) spectroscopy analyzes a wide range of pharmaceutical materials
in a non-disruptive and non-invasive manner. The obtained molecular properties at …

NMR crystallography of molecular organics

P Hodgkinson - Progress in Nuclear Magnetic Resonance …, 2020 - Elsevier
Developments of NMR methodology to characterise the structures of molecular organic
structures are reviewed, concentrating on the previous decade of research in which density …

Investigating miscibility and molecular mobility of nifedipine-PVP amorphous solid dispersions using solid-state NMR spectroscopy

X Yuan, D Sperger, EJ Munson - Molecular pharmaceutics, 2014 - ACS Publications
Solid-state NMR (SSNMR) 1H T1 and T1ρ relaxation times were used to evaluate the
miscibility of amorphous solid dispersions of nifedipine (NIF) and polyvinylpyrrolidone (PVP) …

Fast magic-angle sample spinning solid-state NMR at 60–100 kHz for natural abundance samples

Y Nishiyama - Solid State Nuclear Magnetic Resonance, 2016 - Elsevier
In spite of tremendous progress made in pulse sequence designs and sophisticated
hardware developments, methods to improve sensitivity and resolution in solid-state NMR …

Dynamic nuclear polarization enhanced NMR spectroscopy for pharmaceutical formulations

AJ Rossini, CM Widdifield, A Zagdoun… - Journal of the …, 2014 - ACS Publications
Dynamic nuclear polarization (DNP) enhanced solid-state NMR spectroscopy at 9.4 T is
demonstrated for the detailed atomic-level characterization of commercial pharmaceutical …

Structural and dynamic properties of amorphous solid dispersions: the role of solid-state nuclear magnetic resonance spectroscopy and relaxometry

A Paudel, M Geppi, G Van den Mooter - Journal of pharmaceutical …, 2014 - Elsevier
Amorphous solid dispersions (ASDs) are one of the frontier strategies to improve solubility
and dissolution rate of poorly soluble drugs and hence tackling the growing challenges in …

Interplay of structure and dynamics in functional macromolecular and supramolecular systems as revealed by magnetic resonance spectroscopy

MR Hansen, R Graf, HW Spiess - Chemical Reviews, 2016 - ACS Publications
The characterization of structure and dynamics of macromolecular and supramolecular
systems represents an ongoing challenge. This is due to the fact that soft matter systems …

Molecular interactions in posaconazole amorphous solid dispersions from two-dimensional solid-state NMR spectroscopy

X Lu, C Huang, MB Lowinger, F Yang, W Xu… - Molecular …, 2019 - ACS Publications
Molecular interactions between the active pharmaceutical ingredient and polymer have
potentially substantial impacts on the physical stability of amorphous solid dispersions …

Opportunities and Challenges in Applying Solid‐State NMR Spectroscopy in Organic Mechanochemistry

IAA Silva, E Bartalucci, C Bolm… - Advanced Materials, 2023 - Wiley Online Library
In recent years it is shown that mechanochemical strategies can be beneficial in directed
conversions of organic compounds. Finding new reactions proved difficult, and due to the …