The concept of a matricellular protein was first proposed by Paul Bornstein in the mid-1990s
to account for the non-lethal phenotypes of mice with inactivated genes encoding …

The potent actions of pigment epithelium-derived factor (PEDF) on tumour-associated cells,
and its extracellular localization and secretion, stimulated research on this multifunctional …

Adult stem cells are characterized by self-renewal and multilineage differentiation, and these
properties seem to be regulated by signals from adjacent differentiated cell types and by …

Pigment epithelium-derived factor (PEDF) is a potent and broadly acting neurotrophic factor
that protects neurons in many regions of the central nervous system against insults such as …

Natural inhibitors of angiogenesis are able to block pathological neovascularization without
harming the preexisting vasculature. Here we show that two such inhibitors, thrombospondin …

Aberrant blood vessel growth in the retina that underlies the pathology of proliferative
diabetic retinopathy and retinopathy of prematurity is the result of the ischemia-driven …

Idiopathic pulmonary fibrosis (IPF) is a disabling disease of the lung parenchyma,
characterized by progressive accumulation of scar tissue and myofibroblast activation after …

Pigment epithelium-derived factor (PEDF) is an extracellular multifunctional protein
belonging to the serpin superfamily with demonstrable neurotrophic, gliastatic …

Pigment epithelium-derived factor (PEDF) is a broadly expressed multifunctional member of
the serine proteinase inhibitor (serpin) family. This widely studied protein plays critical roles …

Pigment epithelium-derived factor (PEDF) is a 50-kDa protein encoded by a single gene that
shows strong conservation across phyla from fish to mammals. It is secreted by the retinal …