Alzheimer's disease (AD) is a frequent and disabling neurodegenerative disorder, in which
astrocytes participate in several pathophysiological processes including neuroinflammation …

Despite expressing many key risk genes, the role of microglia in late-onset Alzheimer's
disease pathophysiology is somewhat ambiguous, with various phenotypes reported to be …

Amyloid-like aggregates of the microtubule-associated protein Tau are associated with
several neurodegenerative disorders including Alzheimer's disease. The existence of …

The protein homeostasis (proteostasis) system encompasses the cellular processes that
regulate protein synthesis, folding, concentration, trafficking and degradation. In the case of …

Gene expression is changed by disease, but how these molecular responses arise and
contribute to pathophysiology remains less understood. We discover that β-amyloid, a …

Fibrillar protein aggregates are the pathological hallmark of a group of age‐dependent
neurodegenerative conditions, including Alzheimer's and Parkinson's disease. Aggregates …

Hyper-phosphorylated tau accumulates as insoluble fibrils in Alzheimer's disease (AD) and
related dementias. The strong correlation between phosphorylated tau and disease has led …

Propagation of tau fibrils correlate closely with neurodegeneration and memory deficits seen
during the progression of Alzheimer's disease (AD). Although it is not well-established what …

Many neurodegenerative diseases, including Alzheimer's, originate from the conversion of
proteins into pathogenic conformations. The microtubule-associated protein tau converts …

Eukaryotic cells are equipped with an intricate proteostasis network (PN), comprising nearly
3000 components dedicated to preserving proteome integrity and sustaining protein …