Head-to-head trials in inflammatory bowel disease: past, present and future

L Pouillon, S Travis, P Bossuyt, S Danese… - Nature reviews …, 2020 - nature.com
With the increase in the number of novel drugs for inflammatory bowel disease (IBD),
comparing therapeutic options or strategies has become a key challenge in IBD trials. Head …

Can we change the natural course of inflammatory bowel disease?

C Le Berre, S Danese… - Therapeutic Advances …, 2023 - journals.sagepub.com
Inflammatory bowel diseases (IBD), including Crohn's disease (CD) and ulcerative colitis
(UC), are lifelong diseases characterized by chronic inflammation of the gastrointestinal tract …

Comparative safety and effectiveness of vedolizumab to tumour necrosis factor antagonist therapy for Crohn's disease

M Bohm, R Xu, Y Zhang, S Varma… - Alimentary …, 2020 - Wiley Online Library
Background Direct comparisons are lacking between vedolizumab and tumour necrosis
factor (TNF)‐antagonist therapy in Crohn's disease (CD). Aim To compare safety and …

Vedolizumab trough levels in children with anti-tumor necrosis factor refractory inflammatory bowel disease

MA Aardoom, MME Jongsma, A de Vries… - Journal of Pediatric …, 2020 - journals.lww.com
Objectives: Inflammatory bowel disease (IBD) can be successfully treated with vedolizumab.
Studies in adult IBD patients have shown that differences in response to vedolizumab may …

Prevalence of immunomodulator use as combination therapy with vedolizumab or ustekinumab in inflammatory bowel disease

M Lutz, F Caldera, K Schroeder, D Gazis… - Clinical and …, 2023 - journals.lww.com
METHODS: Clinical information was ascertained from electronic medical records of patients
enrolled in TARGET-IBD, a prospective longitudinal observational cohort of patients with …

Is the writing on the wall? The relationship between the number of disease-modifying anti-inflammatory bowel disease drugs used and the risk of surgical resection

MM Mankarious, AC Greene, EW Schaefer… - Journal of …, 2024 - Elsevier
Background Disease-modifying anti-inflammatory bowel disease drugs (DMAIDs)
revolutionized the management of ulcerative colitis (UC). This study assessed the …

Herpes zoster eruption during vedolizumab therapy: a simple coincidence or more?

GM Garbo, FS Macaluso, S Renna… - Inflammatory Bowel …, 2020 - academic.oup.com
To the editors, Evidence is accumulating about the real-world effectiveness of vedolizumab
(VDZ) for the treatment of inflammatory bowel diseases (IBD). 1, 2 Furthermore, the clinical …

Subcutaneously administered anti-TNFs for the treatment of ulcerative colitis: a retrospective, propensity score-matched, US health claims analysis

MJ Stewart, T Bessissow, J Gregor, M Hazel, TSH In… - Advances in …, 2021 - Springer
Introduction Adalimumab and golimumab are subcutaneously administered anti-tumor
necrosis factor α (TNFα) biologics used in the treatment of ulcerative colitis (UC). To date, no …

Systematic Literature Review and Meta‐analysis: Real‐World Mucosal Healing in Vedolizumab‐Treated Patients with Crohn's Disease

S Danese, P Kamble, J Yang, JG Le Moine… - …, 2022 - Wiley Online Library
Background. Vedolizumab is a gut‐selective monoclonal anti‐α4β7‐integrin antibody
approved for the treatment of adults with moderately to severely active Crohn's disease …

[引用][C] Successful treatment of steroid‐refractory gastrointestinal acute graft‐versus‐host disease with adjuvant vedolizumab therapy in a pediatric allogeneic stem cell …

V Pai, R Abu‐Arja, JJ Auletta… - Pediatric Blood & …, 2020 - Wiley Online Library
Successful treatment of steroid‐refractory gastrointestinal acute graft‐versus‐host disease
with adjuvant vedolizumab therapy in a pediatric allogeneic stem cell transplant recipient …