The Hedgehog signalling pathway has crucial roles in embryonic tissue patterning,
postembryonic tissue regeneration, and cancer, yet aspects of Hedgehog signal …

Since cancer stem cells (CSCs) were first identified in leukemia in 1994, they have been
considered promising therapeutic targets for cancer therapy. These cells have self-renewal …

Chronic myeloid leukemia (CML), caused by constitutively active BCR-ABL1 fusion tyrosine
kinase, has served as a paradigm for successful application of molecularly targeted cancer …

Abstract The Hedgehog (Hh) signaling pathway was first identified in the common fruit fly. It
is a highly conserved evolutionary pathway of signal transmission from the cell membrane to …

Although we have come a long way in our understanding of the signals that drive cancer
growth, and how these signals can be targeted, effective control of this disease remains a …

Acute myeloid leukemia (AML) is the most common form of acute leukemia in adults and the
second most common form of acute leukemia in children. Despite this, very little …

It is well documented that the rate of aging can be slowed, but it remains unclear to which
extent aging-associated conditions can be reversed. How the interface of immunity and …

The sonic hedgehog (Shh) signaling pathway is a major regulator of cell differentiation, cell
proliferation, and tissue polarity. Aberrant activation of the Shh pathway has been shown in …

Proliferation is an important part of cancer development and progression. This is manifest by
altered expression and/or activity of cell cycle related proteins. Constitutive activation of …

Stemness combines the ability of a cell to perpetuate its lineage, to give rise to differentiated
cells, and to interact with its environment to maintain a balance between quiescence …