Central IRF4/5 signaling are critical for microglial activation and impact on stroke outcomes

C Ngwa, A Misrani, KV Manyam, Y Xu, S Qi… - Translational Stroke …, 2025 - Springer

The role of chromatin biology and epigenetics in disease progression is gaining increasing
recognition. Genes that escape X chromosome inactivation (XCI) can impact …

ACE2 Rescues Sepsis-Associated Encephalopathy by Reducing Inflammation, Oxidative Stress, and Neuronal Apoptosis via the Nrf2/Sestrin2 Signaling Pathway

Y Li, TT Wan, JX Li, X Xiao, L Liu, HH Li… - Molecular Neurobiology, 2024 - Springer

Neuroinflammation and oxidative stress contribute to the progression of sepsis-associated
encephalopathy (SAE). Angiotensin-converting enzyme 2 (ACE2) is considered to be a …

被引用次数：4 相关文章所有 3 个版本

MyD88 Inhibition Attenuates Cerebral Ischemia-reperfusion Injury by Regulating the Inflammatory Response and Reducing Blood–brain Barrier Damage

F Jiang, C Xu, X Fan, S Yang, W Fan, J Song, W Wei… - Neuroscience, 2024 - Elsevier

Myeloid differentiation primary response gene 88 (MyD88), a downstream molecule directly
linked to Toll-like receptor (TLRs) and IL1 receptor, has been implicated in ischemia …

被引用次数：2 相关文章所有 4 个版本

ABBV-744 alleviates LPS-induced neuroinflammation via regulation of BATF2-IRF4-STAT1/3/5 axis

L Wang, H Wang, S Lin, X Xu, W Hu, J Liu… - Acta Pharmacologica …, 2024 - nature.com

Suppression of neuroinflammation using small molecule compounds targeting the key
pathways in microglial inflammation has attracted great interest. Recently, increasing …

[HTML][HTML] Brain endothelial CD200 signaling protects brain against ischemic damage

A Misrani, C Ngwa, A Al Mamun, R Sharmeen… - Brain research …, 2024 - Elsevier

Ischemic stroke induced inflammatory responses contribute significantly to neuronal
damage and stroke outcomes. CD200 ligand and its receptor, CD200R, constitute an …

被引用次数：1 相关文章所有 5 个版本