Gene expression in members of the family Bacillaceae becomes compartmentalized after
the distinctive, asymmetrically located sporulation division. It involves complete …

The soil bacterium Bacillus subtilis uses two different developmental pathways to induce
sporulation and the development of genetic competence. Although they use the same …

To reveal mechanisms of DNA damage checkpoint initiation, we structurally and
biochemically analyzed DisA, a protein that controls a Bacillus subtilis sporulation …

Biofilms are structured communities of cells encased in a polymeric matrix and adherent to a
surface, interface or each other. We report here that the soil bacterium Bacillus subtilis forms …

Dividing cells must coordinate cell cycle events to ensure genetic stability. Here we identify
an essential two-component signal transduction protein that controls multiple events in the …

During infection of its hosts, Salmonella enters intestinal epithelial cells. Many Salmonella
typhimurium genes required for bacterial entry into host cells are encoded on a 40 kb …

The spo0J gene of Bacillus subtilis is required for the initiation of sporulation. We show that
the sporulation defect caused by null mutations in spo0J is suppressed by a null mutation in …

From microbes to multicellular eukaryotic organisms, all cells contain pathways responsible
for genome maintenance. DNA replication allows for the faithful duplication of the genome …

We identified a signaling pathway that prevents initiation of sporulation in Bacillus subtilis
when replication initiation is impaired. We isolated mutations that allow a replication …

Development of genetic competence in Bacillus subtilis is regulated by extracellular
signaling molecules, including the ComX pheromone, a modified 9-or 10-amino-acid …