TGF-β uncouples glycolysis and inflammation in macrophages and controls survival during sepsis
Changes in metabolism of macrophages are required to sustain macrophage activation in
response to different stimuli. We showed that the cytokine TGF-β (transforming growth factor …
response to different stimuli. We showed that the cytokine TGF-β (transforming growth factor …
Locus of (IL-9) control: IL9 epigenetic regulation in cellular function and human disease
A Son, I Baral, GH Falduto, DM Schwartz - Experimental & Molecular …, 2024 - nature.com
Abstract Interleukin-9 (IL-9) is a multifunctional cytokine with roles in a broad cross-section of
human diseases. Like many cytokines, IL-9 is transcriptionally regulated by a group of …
human diseases. Like many cytokines, IL-9 is transcriptionally regulated by a group of …
The dichotomy of interleukin-9 function in the tumor microenvironment
A Cannon, A Pajulas, MH Kaplan… - Journal of Interferon & …, 2023 - liebertpub.com
Interleukin 9 (IL-9) is a cytokine with potent proinflammatory properties that plays a central
role in pathologies such as allergic asthma, immunity to parasitic infection, and …
role in pathologies such as allergic asthma, immunity to parasitic infection, and …
Fatty acid metabolism constrains Th9 cell differentiation and antitumor immunity via the modulation of retinoic acid receptor signaling
T Nakajima, T Kanno, Y Ueda, K Miyako… - Cellular & Molecular …, 2024 - nature.com
Abstract T helper 9 (Th9) cells are interleukin 9 (IL-9)-producing cells that have diverse
functions ranging from antitumor immune responses to allergic inflammation. Th9 cells …
functions ranging from antitumor immune responses to allergic inflammation. Th9 cells …
Notch4 participates in mesenchymal stem cell-induced differentiation in 3D-printed matrix and is implicated in eccrine sweat gland morphogenesis
Y Wang, F Zhang, B Yao, L Hou, Z Li, W Song… - Burns & …, 2023 - academic.oup.com
Background Eccrine sweat gland (SG) plays a crucial role in thermoregulation but exhibits
very limited regenerative potential. Although SG lineage-restricted niches dominate SG …
very limited regenerative potential. Although SG lineage-restricted niches dominate SG …
MicroRNA-19b exacerbates systemic sclerosis through promoting Th9 cells
Systemic sclerosis (SSc) is a chronic autoimmune disease characterized by fibrosis of the
skin and multiple vital organs, but the immunological pathogenesis of SSc remains unclear …
skin and multiple vital organs, but the immunological pathogenesis of SSc remains unclear …
[HTML][HTML] A reappraisal of IL-9 in inflammation and cancer
F Bick, C Blanchetot, BN Lambrecht, MJ Schuijs - Mucosal Immunology, 2024 - Elsevier
While much is known about the functional effects of type 2 cytokines interleukin (IL)-4, IL-5
and IL-13 in homeostasis and disease, we still poorly understand the functions of IL-9 …
and IL-13 in homeostasis and disease, we still poorly understand the functions of IL-9 …
Transcription Factor Id1 Plays an Essential Role in Th9 Cell Differentiation by Inhibiting Tcf3 and Tcf4
WH Lee, KJ Hong, HB Li, GR Lee - Advanced Science, 2023 - Wiley Online Library
Abstract T helper type 9 (Th9) cells play important roles in immune responses by producing
interleukin‐9 (IL‐9). Several transcription factors are responsible for Th9 cell differentiation; …
interleukin‐9 (IL‐9). Several transcription factors are responsible for Th9 cell differentiation; …
Microglial DBP Signaling Mediates Behavioral Abnormality Induced by Chronic Periodontitis in Mice
T Cao, D Tian, SY Wang, Y Pan, ZX Xia… - Advanced …, 2024 - Wiley Online Library
Several lines of evidence implicate that chronic periodontitis (CP) increases the risk of
mental illnesses, such as anxiety and depression, yet, the associated molecular mechanism …
mental illnesses, such as anxiety and depression, yet, the associated molecular mechanism …
[HTML][HTML] Circadian clock component PER2 negatively regulates CD4+ T cell IFN-γ production in ulcerative colitis
Y Ye, C Liu, R Wu, D Kang, H Gao, H Lv, Z Feng… - Mucosal …, 2024 - Elsevier
Abstract Period circadian clock 2 (PER2) is involved in the pathogenesis of various
inflammatory and autoimmune diseases. However, there are gaps in our understanding of …
inflammatory and autoimmune diseases. However, there are gaps in our understanding of …