TGF-β uncouples glycolysis and inflammation in macrophages and controls survival during sepsis

T Gauthier, C Yao, T Dowdy, W Jin, YJ Lim… - Science …, 2023 - science.org
Changes in metabolism of macrophages are required to sustain macrophage activation in
response to different stimuli. We showed that the cytokine TGF-β (transforming growth factor …

Locus of (IL-9) control: IL9 epigenetic regulation in cellular function and human disease

A Son, I Baral, GH Falduto, DM Schwartz - Experimental & Molecular …, 2024 - nature.com
Abstract Interleukin-9 (IL-9) is a multifunctional cytokine with roles in a broad cross-section of
human diseases. Like many cytokines, IL-9 is transcriptionally regulated by a group of …

The dichotomy of interleukin-9 function in the tumor microenvironment

A Cannon, A Pajulas, MH Kaplan… - Journal of Interferon & …, 2023 - liebertpub.com
Interleukin 9 (IL-9) is a cytokine with potent proinflammatory properties that plays a central
role in pathologies such as allergic asthma, immunity to parasitic infection, and …

Fatty acid metabolism constrains Th9 cell differentiation and antitumor immunity via the modulation of retinoic acid receptor signaling

T Nakajima, T Kanno, Y Ueda, K Miyako… - Cellular & Molecular …, 2024 - nature.com
Abstract T helper 9 (Th9) cells are interleukin 9 (IL-9)-producing cells that have diverse
functions ranging from antitumor immune responses to allergic inflammation. Th9 cells …

Notch4 participates in mesenchymal stem cell-induced differentiation in 3D-printed matrix and is implicated in eccrine sweat gland morphogenesis

Y Wang, F Zhang, B Yao, L Hou, Z Li, W Song… - Burns & …, 2023 - academic.oup.com
Background Eccrine sweat gland (SG) plays a crucial role in thermoregulation but exhibits
very limited regenerative potential. Although SG lineage-restricted niches dominate SG …

MicroRNA-19b exacerbates systemic sclerosis through promoting Th9 cells

YJ Lim, SA Park, D Wang, W Jin, WL Ku, D Zhang, J Xu… - Cell reports, 2024 - cell.com
Systemic sclerosis (SSc) is a chronic autoimmune disease characterized by fibrosis of the
skin and multiple vital organs, but the immunological pathogenesis of SSc remains unclear …

[HTML][HTML] A reappraisal of IL-9 in inflammation and cancer

F Bick, C Blanchetot, BN Lambrecht, MJ Schuijs - Mucosal Immunology, 2024 - Elsevier
While much is known about the functional effects of type 2 cytokines interleukin (IL)-4, IL-5
and IL-13 in homeostasis and disease, we still poorly understand the functions of IL-9 …

Transcription Factor Id1 Plays an Essential Role in Th9 Cell Differentiation by Inhibiting Tcf3 and Tcf4

WH Lee, KJ Hong, HB Li, GR Lee - Advanced Science, 2023 - Wiley Online Library
Abstract T helper type 9 (Th9) cells play important roles in immune responses by producing
interleukin‐9 (IL‐9). Several transcription factors are responsible for Th9 cell differentiation; …

Microglial DBP Signaling Mediates Behavioral Abnormality Induced by Chronic Periodontitis in Mice

T Cao, D Tian, SY Wang, Y Pan, ZX Xia… - Advanced …, 2024 - Wiley Online Library
Several lines of evidence implicate that chronic periodontitis (CP) increases the risk of
mental illnesses, such as anxiety and depression, yet, the associated molecular mechanism …

[HTML][HTML] Circadian clock component PER2 negatively regulates CD4+ T cell IFN-γ production in ulcerative colitis

Y Ye, C Liu, R Wu, D Kang, H Gao, H Lv, Z Feng… - Mucosal …, 2024 - Elsevier
Abstract Period circadian clock 2 (PER2) is involved in the pathogenesis of various
inflammatory and autoimmune diseases. However, there are gaps in our understanding of …