Astrocytes are the most abundant cell type within the central nervous system. They play
essential roles in maintaining normal brain function, as they are a critical structural and …

Inflammation plays an important role in the pathogenesis of ischemic stroke and other forms
of ischemic brain injury. Increasing evidence suggests that inflammatory response is a …

Circular RNAs (circRNAs) are highly expressed in the central nervous system and are
involved in the regulation of physiological and pathophysiological processes. However, the …

Brain ischemia elicits microglial activation and microglia survival depend on signaling
through colony-stimulating factor 1 receptor (CSF1R). Although depletion of microglia has …

Acute ischaemic stroke accounts for 6.5 million deaths per year, and by 2030 will result in
the annual loss of over 200 million disability-adjusted life years globally. There have been …

In the past two decades, over 1000 clinical trials have failed to demonstrate a benefit in
treating stroke, with the exception of thrombolytics. Although many targets have been …

Astrocytes are believed to bridge interactions between infiltrating lymphocytes and neurons
during brain ischemia, but the mechanisms for this action are poorly understood. Here we …

Background Investigations following stroke first of all require information about the spatio-
temporal dimension of the ischemic core as well as of perilesional and remote affected …

Replacing the tissue lost after a stroke potentially provides a new neural substrate to
promote recovery. However, significant neurobiological and biotechnological challenges …

The cell cycle is a delicately manipulated process essential for the development,
differentiation, proliferation and death of cells. Inappropriate activation of cell cycle …