Parietal cells are responsible for gastric acid secretion, which aids in the digestion of food,
absorption of minerals, and control of harmful bacteria. However, a fine balance of activators …

We continue to make progress in our understanding of the regulation of gastric acid
secretion in health and disease. A better understanding of the pathways and mechanisms …

Gastric acid secretion (i) facilitates digestion of protein as well as absorption of
micronutrients and certain medications,(ii) kills ingested microorganisms, including …

Although none of the recent findings produced on somatostatin seem ready to be
considered for clinical application, recent developments of animal models such as SSTR …

Extracellular nucleotides and adenosine are biologically active molecules that bind
members of the P2 and P1 receptor families, respectively. In the digestive system, these …

Glucose-dependent insulinotropic polypeptide (GIP) is a hormone released from
enteroendocrine K cells in response to meals. Posttranslational processing of the precursor …

Composed by a molecule of adenine and a molecule of ribose, adenosine is a paradigm of
recyclable nucleoside with a multiplicity of functions that occupies a privileged position in the …

Extracellular nucleotides and nucleosides are crucial signalling molecules, eliciting diverse
biological responses in almost all organs and tissues. These molecules exert their effects by …

Adenosine is readily available to the glandular epithelium of the stomach. Formed
continuously in intracellular and extracellular locations, it is notably produced from ATP …

The importance of gastrointestinal peptides for regulating gastric acid is evident. Ongoing
investigations will characterize the mechanisms underlying actions of these agents on …