Carbonic anhydrase IX: A tumor acidification switch in heterogeneity and chemokine regulation
The primary physiological process of respiration produces carbon dioxide (CO 2) that reacts
with water molecules which subsequently liberates bicarbonate (HCO–3) and protons …
with water molecules which subsequently liberates bicarbonate (HCO–3) and protons …
A novel series of thiosemicarbazone hybrid scaffolds: Design, synthesis, DFT studies, metabolic enzyme inhibition properties, and molecular docking calculations
The fourteen new thiosemicarbazone derivatives of Schiff base were synthesized from the
condensation reactions of two different aldehydes (3‑hydroxy-4-methoxhybenzaldehyde and …
condensation reactions of two different aldehydes (3‑hydroxy-4-methoxhybenzaldehyde and …
Naringenin as a potential inhibitor of human cyclin-dependent kinase 6: Molecular and structural insights into anti-cancer therapeutics
Cancer is one of the major causes of global deaths and needs immediate therapeutic
development. So far, several strategies have been undertaken to prevent cancer, including …
development. So far, several strategies have been undertaken to prevent cancer, including …
Small structural differences govern the carbonic anhydrase II inhibition activity of cytotoxic triterpene acetazolamide conjugates
TC Denner, N Heise, J Zacharias, O Kraft, S Hoenke… - Molecules, 2023 - mdpi.com
Acetylated triterpenoids betulin, oleanolic acid, ursolic acid, and glycyrrhetinic acid were
converted into their succinyl-spacered acetazolamide conjugates. These conjugates were …
converted into their succinyl-spacered acetazolamide conjugates. These conjugates were …
Synthesis, antimicrobial evaluation and docking studies of oxazolone-1, 2, 3-triazole-amide hybrids
In an attempt to develop quality antimicrobial agents, a series of oxazolone-1, 2, 3-triazole-
amide hybrids were obtained from oxazolone tethered with a terminal alkyne and in situ …
amide hybrids were obtained from oxazolone tethered with a terminal alkyne and in situ …
Design, synthesis, in-vitro biological profiling and molecular docking of some novel oxazolones and imidazolones exhibiting good inhibitory potential against …
I Saleem Naz Babari, M Islam, H Saeed… - Journal of …, 2024 - Taylor & Francis
Heterocyclic compounds with oxazole and imidazole rings in their structure have disclosed
momentous biological aptitudes. Taking into account their superlative attributes, the present …
momentous biological aptitudes. Taking into account their superlative attributes, the present …
Structure based exploration of mitochondrial alpha carbonic anhydrase inhibitors as potential leads for anti-obesity drug development
I Padhy, T Sharma, B Banerjee, S Mohapatra… - DARU Journal of …, 2024 - Springer
Background Obesity has emerged as a major health challenge globally in the last two
decades. Dysregulated fatty acid metabolism and de novo lipogenesis are prime causes for …
decades. Dysregulated fatty acid metabolism and de novo lipogenesis are prime causes for …
Discovery of natural compounds as potential inhibitors of human carbonic anhydrase II: An integrated virtual screening, docking, and molecular dynamics simulation …
Carbonic anhydrase II (CAII) is one of the zinc metalloenzymes that catalyze the reversible
hydration of carbon dioxide, leading to the formation of bicarbonate and proton. CAII plays a …
hydration of carbon dioxide, leading to the formation of bicarbonate and proton. CAII plays a …
Structure-guided design and development of vanillin-triazole conjugates as potential MARK4 inhibitors targeting hepatocellular carcinoma
Microtubule affinity-regulating kinase 4 (MARK4) is a potential therapeutic target for cancer
therapy, as it plays a crucial role in cell division and metastasis. Vanillin is an essential …
therapy, as it plays a crucial role in cell division and metastasis. Vanillin is an essential …
Vanillin-Isatin Hybrid-Induced MARK4 Inhibition As a Promising Therapeutic Strategy against Hepatocellular Carcinoma
Microtubule affinity-regulating kinase 4 (MARK4) is a serine-threonine kinase that
phosphorylates microtubule-associated proteins (MAPs) and increases the microtubule …
phosphorylates microtubule-associated proteins (MAPs) and increases the microtubule …