The type I human immunodeficiency virus (HIV‐1) pandemic affecting over 37 million people
worldwide continues, with 1.8 million people newly infected each year. Highly active …

Human immunodeficiency virus type I (HIV-1) is a retrovirus that infects cells of the host's
immune system leading to acquired immunodeficiency syndrome and potentially death …

Non-nucleoside reverse transcriptase inhibitors (NNRTIs) are part of a structurally diverse
family with distinct features attractive for the treatment of AIDS that continues to be a major …

Formation of active HIV-1 reverse transcriptase (RT) proceeds via a structural maturation
process that involves subdomain rearrangements and formation of an asymmetric …

Paramagnetism‐assisted nuclear magnetic resonance (NMR) techniques can provide long‐
range structural information complemented with local information derived from chemical …

Reverse transcriptase (RT) is the target for the majority of anti-HIV-1 drugs. As with all anti-
AIDS treatments, continued success of RT inhibitors is persistently disrupted by the …

The human immunodeficiency virus (HIV) which is strictly related to the development of
AIDS, is treated by a cocktail of drugs, but due its high propensity gain drug resistance, the …

Abstract Human immunodeficiency virus (HIV)-1 reverse transcriptase (HIV-1 RT) is
responsible for the transcription of viral RNA genomes into DNA genomes and has become …

NMR studies of large proteins, over 100 kDa, in solution are technically challenging and,
therefore, of considerable interest in the biophysics field. The challenge arises because the …

The human immunodeficiency virus type-1 Reverse Transcriptase (HIV-1 RT) plays a pivotal
role in essential viral replication and is the main target for antiviral therapy. The anti-HIV-1 …