Bergenia Genus: Traditional Uses, Phytochemistry and Pharmacology

B Koul, A Kumar, D Yadav, JO Jin - Molecules, 2020 - mdpi.com
Bergenia (Saxifragaceae) genus is native to central Asia and encompasses 32 known
species. Among these, nine are of pharmacological relevance. In the Indian system of …

Diversity, pharmacology and synthesis of bergenin and its derivatives: Potential materials for therapeutic usages

GB Bajracharya - Fitoterapia, 2015 - Elsevier
Bergenin, a natural secondary metabolite, has been isolated from different parts of a number
of plants. It is one of active ingredients in herbal and Ayurvedic formulations. It exhibits …

[HTML][HTML] Anti-inflammatory effects of carvacrol: evidence for a key role of interleukin-10

M da Silva Lima, LJ Quintans-Junior… - European journal of …, 2013 - Elsevier
Carvacrol, a phenolic monoterpene, has been reported to possess anti-inflammatory
properties. However, the mechanisms involved in its pharmacological properties are …

Antihyperalgesic properties of honokiol in inflammatory pain models by targeting of NF-κB and Nrf2 signaling

S Khalid, MZ Ullah, AU Khan, R Afridi… - Frontiers in …, 2018 - frontiersin.org
The present study investigates the possible anti-nociceptive effect of intraperitoneal (ip)
honokiol: a phenolic compound originally isolated from Magnolia officinalis, in acute and …

The natural product bergenin ameliorates lipopolysaccharide-induced acute lung injury by inhibiting NF-kappaB activition

S Yang, Z Yu, L Wang, T Yuan, X Wang… - Journal of …, 2017 - Elsevier
Ethnopharmacological relevance Bergenin, an active constituent of the plants of the genus
Bergenia, was reported to have anti-inflammatory effects in the treatment of chronic …

Antinociceptive properties of 25‐methoxy hispidol A, a triterpinoid isolated from Poncirus trifoliata (Rutaceae) through inhibition of NF‐κB signalling in mice

A Khan, MZ Ullah, R Afridi, H Rasheed… - Phytotherapy …, 2019 - Wiley Online Library
The 25‐methoxy hispidol A (25‐MHA) is a triterpenoid, isolated from the immature fruit of
Poncirus trifoliata (Rutaceae). The pretreatment with 25‐MHA markedly (p< 0.001) …

Bergenin reduces experimental painful diabetic neuropathy by restoring redox and immune homeostasis in the nervous system

CF Villarreal, DS Santos, PSS Lauria, KB Gama… - International Journal of …, 2020 - mdpi.com
Diabetic neuropathy is a frequent complication of diabetes. Symptoms include neuropathic
pain and sensory alterations—no effective treatments are currently available. This work …

[HTML][HTML] Natural chromones as potential anti-inflammatory agents: Pharmacological properties and related mechanisms

LCF Opretzka, RF do Espirito-Santo… - International …, 2019 - Elsevier
Chromones are a group of natural substances with a diversity of biological activities. Herein
we assessed the pharmacological potential of three chromones (1, 2 and 3) isolated from …

Bergenin loaded gum xanthan stabilized silver nanoparticles suppress synovial inflammation through modulation of the immune response and oxidative stress in …

K Rao, T Roome, S Aziz, A Razzak, G Abbas… - Journal of Materials …, 2018 - pubs.rsc.org
Bergenin (BG) is a naturally occurring C-glycoside with demonstrated anti-arthritic potential.
Its therapeutic efficacy is compromised due to its lower absorption and instability at neutral …

Molecular mechanism of capillarisin-mediated inhibition of MyD88/TIRAP inflammatory signaling in in vitro and in vivo experimental models

S Khan, RJ Choi, O Shehzad, HP Kim, MN Islam… - Journal of …, 2013 - Elsevier
ETHNOPHARMACOLOGICAL RELEVANCE: Artemisia capillaris Thunberg (Compositae)
have been used as traditional medicine as a diuretic, liver protective agent, and for …