[HTML][HTML] Combining copper and zinc into a biosensor for anti-chemoresistance and achieving osteosarcoma therapeutic efficacy

YY Lim, AMA Zaidi, A Miskon - Molecules, 2023 - mdpi.com
Due to its built-up chemoresistance after prolonged usage, the demand for replacing
platinum in metal-based drugs (MBD) is rising. The first MBD approved by the FDA for …

Nanotechnology in the diagnostic and therapy for Alzheimer's disease

A Panghal, SJS Flora - Biochimica et Biophysica Acta (BBA)-General …, 2024 - Elsevier
Alzheimer's disease (AD) is a neurodegenerative disorder primarily characterized by β-
amyloid plaque, intraneuronal tangles, significant neuronal loss and cognitive deficit …

Advances in the discovery of heterocyclic-based drugs against Alzheimer's disease

JD Sánchez, AR Alcántara, JF González… - Expert Opinion on …, 2023 - Taylor & Francis
Introduction Alzheimer's disease is a multifactorial neurodegenerative disorder
characterized by beta-amyloid accumulation and tau protein hyperphosphorylation. The …

ADVANCES IN ALZHEIMER'S DISEASE: A MULTIFACETED REVIEW OF POTENTIAL THERAPIES AND DIAGNOSTIC TECHNIQUES FOR EARLY DETECTION

M Sharma, P Pal, SK Gupta - Neurochemistry International, 2024 - Elsevier
Alzheimer's disease (AD) remains one of the most formidable neurological disorders,
affecting millions globally. This review provides a holistic overview of the therapeutic …

[HTML][HTML] The Impact of Hydroxytyrosol on the Metallomic-Profile in an Animal Model of Alzheimer's Disease

M Tabanez, IR Santos, JM Ikebara… - International Journal of …, 2023 - mdpi.com
It is undeniable that as people get older, they become progressively more susceptible to
neurodegenerative illnesses such as Alzheimer's disease (AD). Memory loss is a prominent …

Navigating the Maze of Alzheimer's Disease by Exploring BACE1: Discovery, Current Scenario, and Future Prospects

F Iram, M Shahid, J Ansari, GM Ashraf… - Ageing Research …, 2024 - Elsevier
Alzheimer's disease (AD) is a chronic neurological condition that has become a leading
cause of cognitive decline in elder individuals. Hardly any effective medication has been …

Label-Free In Situ Chemical Characterization of Amyloid Plaques in Human Brain Tissues

J Everett, J Brooks, V Tjendana Tjhin… - ACS Chemical …, 2024 - ACS Publications
The accumulation of amyloid plaques and increased brain redox burdens are
neuropathological hallmarks of Alzheimer's disease. Altered metabolism of essential …

[HTML][HTML] N-Based Polydentate Ligands and Corresponding Zn (II) Complexes: A Structural and Spectroscopic Study

G Volpi, S Zago, R Rabezzana, E Diana, E Priola… - Inorganics, 2023 - mdpi.com
Herein, the structural and photophysical features of two N-based polydentate ligands and
the corresponding Zn (II) complexes are investigated. The obtained compounds were …

[HTML][HTML] Imidazopyridine Family: Versatile and Promising Heterocyclic Skeletons for Different Applications

G Volpi, E Laurenti, R Rabezzana - Molecules, 2024 - mdpi.com
In recent years, there has been increasing attention focused on various products belonging
to the imidazopyridine family; this class of heterocyclic compounds shows unique chemical …

Copper: From enigma to therapeutic target for neurological disorder

J Patwa, SJS Flora - Basic & Clinical Pharmacology & …, 2024 - Wiley Online Library
Neurological disorders (NDs) have a negative impact on the lives of individuals. There could
be two explanations for this: unclear aetiology and lack of effective therapy. However …