[PDF][PDF] Oxidative stress-mediated epigenetic regulation by G-quadruplexes
AM Fleming, CJ Burrows - NAR cancer, 2021 - academic.oup.com
Many cancer-associated genes are regulated by guanine (G)-rich sequences that are
capable of refolding from the canonical duplex structure to an intrastrand G-quadruplex …
capable of refolding from the canonical duplex structure to an intrastrand G-quadruplex …
Functions of the major abasic endonuclease (APE1) in cell viability and genotoxin resistance
DR McNeill, AM Whitaker, WJ Stark, JL Illuzzi… - …, 2020 - academic.oup.com
DNA is susceptible to a range of chemical modifications, with one of the most frequent
lesions being apurinic/apyrimidinic (AP) sites. AP sites arise due to damage-induced (eg …
lesions being apurinic/apyrimidinic (AP) sites. AP sites arise due to damage-induced (eg …
A DNA repair pathway can regulate transcriptional noise to promote cell fate transitions
INTRODUCTION Fluctuations have long been known to dynamically shape microstate
distributions in physical systems. Throughout engineering,“dithering” approaches that …
distributions in physical systems. Throughout engineering,“dithering” approaches that …
The human AP-endonuclease 1 (APE1) is a DNA G-quadruplex structure binding protein and regulates KRAS expression in pancreatic ductal adenocarcinoma cells
S Pramanik, Y Chen, H Song, I Khutsishvili… - Nucleic acids …, 2022 - academic.oup.com
Pancreatic ductal adenocarcinoma (PDAC), one of the most aggressive types of cancer, is
characterized by aberrant activity of oncogenic KRAS. A nuclease-hypersensitive GC-rich …
characterized by aberrant activity of oncogenic KRAS. A nuclease-hypersensitive GC-rich …
APE1 distinguishes DNA substrates in exonucleolytic cleavage by induced space-filling
TC Liu, CT Lin, KC Chang, KW Guo, S Wang… - Nature …, 2021 - nature.com
The exonuclease activity of Apurinic/apyrimidinic endonuclease 1 (APE1) is responsible for
processing matched/mismatched terminus in various DNA repair pathways and for removing …
processing matched/mismatched terminus in various DNA repair pathways and for removing …
APE1 recruits ATRIP to ssDNA in an RPA-dependent and-independent manner to promote the ATR DNA damage response
Cells have evolved the DNA damage response (DDR) pathways in response to DNA
replication stress or DNA damage. In the ATR-Chk1 DDR pathway, it has been proposed …
replication stress or DNA damage. In the ATR-Chk1 DDR pathway, it has been proposed …
Binding of AP Endonuclease-1 to G-Quadruplex DNA Depends on the N-Terminal Domain, Mg2+, and Ionic Strength
AM Fleming, SA Howpay Manage… - ACS bio & med chem …, 2021 - ACS Publications
The base excision repair enzyme apurinic/apyrimidinic endonuclease-1 (APE1) is also
engaged in transcriptional regulation. APE1 can function in both pathways when the protein …
engaged in transcriptional regulation. APE1 can function in both pathways when the protein …
Nuclear translocation of RIG-I promotes cellular apoptosis
C Wang, W Zhou, Y Liu, Y Xu, X Zhang, C Jiang… - Journal of …, 2022 - Elsevier
Cell death is important in the elimination of damaged cells such as virus-infected cells and
also is closely involved in the pathogenesis of autoimmune diseases such as systemic lupus …
also is closely involved in the pathogenesis of autoimmune diseases such as systemic lupus …
A novel self-feedback biosensor for label-free detection of APE1 by primer exchange reaction and rolling circle amplification/dimeric G-quadruplex
Y Qi, Y Du, Q Kang, X Yang, H Xiang - Microchemical Journal, 2023 - Elsevier
Human apurinic/apyrimidinic endonuclease 1 (APE1), a critical DNA base excision repair
enzyme, plays a fundamental role in nucleotide damage repair and transcriptional …
enzyme, plays a fundamental role in nucleotide damage repair and transcriptional …
Label-free and highly sensitive APE1 detection based on rolling circle amplification combined with G-quadruplex
B Liu, Z Yang, T Huang, MM Li, W Duan, B Xie… - Talanta, 2022 - Elsevier
The highly sensitive detection of low-abundant apurinic/apyrimidinic endonuclease 1
(APE1) activity is of great significance for early diagnosis of disease and pathological …
(APE1) activity is of great significance for early diagnosis of disease and pathological …