With the increasing morbidity and mortality of invasive fungal infections and the emergence
of severe antifungal drug resistance, new drug targets and novel antifungal agents are …

Neglected tropical diseases (NTDs) constitute a group of approximately 20 infectious
diseases that mainly affect the impoverished population without basic sanitation in tropical …

Protein N-myristoylation enables localization to membranes and helps maintain protein
conformation and function. N-myristoyltransferases (NMT) catalyze co-or posttranslational …

Based on benzoxazole and benzothiazole scaffold as an important pharmacophore, two
series of 2-(aryloxymethyl) benzoxazole and benzothiazole derivatives were synthesized …

A new series of 2, 5 and 1, 5-regioisomers of the tetrazolyl group viz., 3-[(5-benzyl/benzylthio-
2H-tetrazol-2-yl) methyl]-2-chloro-6-substituted quinoline 6h-q and 3-[(5-benzyl/benzylthio …

Each year, approximately 50,000 children under 5 die as a result of diarrhea caused by
Cryptosporidium parvum, a protozoan parasite. There are currently no effective drugs or …

Recent clinical trials investigating treatment of chronic indeterminate Chagas disease with
two re-purposed azole anti-fungal drugs, posaconazole and ravuconazole, revealed their …

In the present work, OECD guidelines have been followed for developing QSAR
(Quantitative Structure-Activity Relationship) models for anti-HAT (Human African …

The development of next-generation antifungal agents with novel chemical scaffolds and
new mechanisms of action is vital due to increased incidence and mortality of invasive …

Fibroblast growth factor (FGF)/FGF receptor (FGFR) signaling facilitates tumor initiation and
progression. Although currently approved inhibitors of FGFR kinase have shown therapeutic …