[HTML][HTML] Excitotoxicity and stroke: identifying novel targets for neuroprotection
Excitotoxicity, the specific type of neurotoxicity mediated by glutamate, may be the missing
link between ischemia and neuronal death, and intervening the mechanistic steps that lead …
link between ischemia and neuronal death, and intervening the mechanistic steps that lead …
[HTML][HTML] Therapeutic potential of N-methyl-D-aspartate receptor modulators in psychiatry
Abstract N-methyl-D-aspartate (NMDA) receptors mediate a slow component of excitatory
synaptic transmission, are widely distributed throughout the central nervous system, and …
synaptic transmission, are widely distributed throughout the central nervous system, and …
A vicious cycle of β amyloid–dependent neuronal hyperactivation
β-amyloid (Aβ)–dependent neuronal hyperactivity is believed to contribute to the circuit
dysfunction that characterizes the early stages of Alzheimer's disease (AD). Although …
dysfunction that characterizes the early stages of Alzheimer's disease (AD). Although …
[HTML][HTML] Synaptic and extrasynaptic NMDA receptors are gated by different endogenous coagonists
N-methyl-d-aspartate receptors (NMDARs) are located in neuronal cell membranes at
synaptic and extrasynaptic locations, where they are believed to mediate distinct …
synaptic and extrasynaptic locations, where they are believed to mediate distinct …
NMDA receptor subunits: diversity, development and disease
N-methyl-d-aspartate receptors (NMDARs) are present at many excitatory glutamate
synapses in the central nervous system and display unique properties that depend on their …
synapses in the central nervous system and display unique properties that depend on their …
[HTML][HTML] Neuronal synchrony mediated by astrocytic glutamate through activation of extrasynaptic NMDA receptors
Fast excitatory neurotransmission is mediated by activation of synaptic ionotropic glutamate
receptors. In hippocampal slices, we report that stimulation of Schaffer collaterals evokes in …
receptors. In hippocampal slices, we report that stimulation of Schaffer collaterals evokes in …
Receptor trafficking and synaptic plasticity
GL Collingridge, JTR Isaac, YT Wang - Nature reviews neuroscience, 2004 - nature.com
Long-term potentiation and long-term depression are processes that have been widely
studied to understand the molecular basis of information storage in the brain. Glutamate …
studied to understand the molecular basis of information storage in the brain. Glutamate …
Cortico-striatal synaptic defects and OCD-like behaviours in Sapap3-mutant mice
JM Welch, J Lu, RM Rodriguiz, NC Trotta, J Peca… - Nature, 2007 - nature.com
Obsessive-compulsive disorder (OCD) is an anxiety-spectrum disorder characterized by
persistent intrusive thoughts (obsessions) and repetitive actions (compulsions). Dysfunction …
persistent intrusive thoughts (obsessions) and repetitive actions (compulsions). Dysfunction …
NMDA receptor subunits have differential roles in mediating excitotoxic neuronal death both in vitro and in vivo
Well-documented experimental evidence from both in vitro and in vivo models of stroke
strongly supports the critical involvement of NMDA receptor-mediated excitotoxicity in …
strongly supports the critical involvement of NMDA receptor-mediated excitotoxicity in …
[HTML][HTML] Early increase in extrasynaptic NMDA receptor signaling and expression contributes to phenotype onset in Huntington's disease mice
AJ Milnerwood, CM Gladding, MA Pouladi… - Neuron, 2010 - cell.com
N-methyl-D-aspartate receptor (NMDAR) excitotoxicity is implicated in the pathogenesis of
Huntington's disease (HD), a late-onset neurodegenerative disorder. However, NMDARs …
Huntington's disease (HD), a late-onset neurodegenerative disorder. However, NMDARs …