Complement has long been considered a key innate immune effector system that mediates
host defence and tissue homeostasis. Yet, growing evidence has illuminated a broader …

The complement system is an ancient collection of proteolytic cascades with well-described
roles in regulation of innate and adaptive immunity. With the convergence of a revolution in …

C3 is the central effector molecule of the complement system, mediating its multiple
functions through different binding sites and their corresponding receptors. We will introduce …

Complement is involved in developmental synaptic pruning and pathological synapse loss
in Alzheimer's disease. It is posited that C1 binding initiates complement activation on …

Dysregulation of the alternative complement pathway predisposes individuals to a number
of diseases. It can either be evoked by genetic alterations in or by stabilizing antibodies to …

Objective A limited range of neuropsychiatric symptoms have been reported in systemic
autoimmune rheumatic diseases (SARDs), with varied symptom prevalence. This study …

Neuroinflammation is the precursor for several neurodegenerative diseases (NDDs), such
as Alzheimer's disease (AD), Parkinson's disease (PD), and multiple sclerosis (MS) …

The complement system is implicated in a broad range of neuroinflammatory disorders such
as Alzheimer's disease (AD) and multiple sclerosis (MS). Consequently, measuring …

Therapeutic interventions in the complement system, a key immune‐inflammatory mediator
and contributor to a broad range of clinical conditions, have long been considered important …

Complement activation is implicated in driving brain inflammation, self-cell damage and
progression of injury in Alzheimer's disease and other neurodegenerative diseases. Here …