Agent‐based models in translational systems biology
G An, Q Mi, J Dutta‐Moscato… - … : Systems Biology and …, 2009 - Wiley Online Library
Effective translational methodologies for knowledge representation are needed in order to
make strides against the constellation of diseases that affect the world today. These …
make strides against the constellation of diseases that affect the world today. These …
Systems medicine: the future of medical genomics and healthcare
High-throughput technologies for DNA sequencing and for analyses of transcriptomes,
proteomes and metabolomes have provided the foundations for deciphering the structure …
proteomes and metabolomes have provided the foundations for deciphering the structure …
Microphysiological engineering of self-assembled and perfusable microvascular beds for the production of vascularized three-dimensional human microtissues
The vasculature is an essential component of the circulatory system that plays a vital role in
the development, homeostasis, and disease of various organs in the human body. The …
the development, homeostasis, and disease of various organs in the human body. The …
Anti-inflammatory effect of vagus nerve stimulation in a rat model of inflammatory bowel disease
J Meregnani, D Clarençon, M Vivier… - Autonomic …, 2011 - Elsevier
Vagus nerve stimulation of afferents is used as an adjunctive treatment for drug-resistant
epilepsy and depression. In addition, anti-inflammatory properties of vagus nerve stimulation …
epilepsy and depression. In addition, anti-inflammatory properties of vagus nerve stimulation …
The shift of an intestinal “microbiome” to a “pathobiome” governs the course and outcome of sepsis following surgical injury
MA Krezalek, J DeFazio, O Zaborina, A Zaborin… - Shock, 2016 - journals.lww.com
Sepsis following surgical injury remains a growing and worrisome problem following both
emergent and elective surgery. Although early resuscitation efforts and prompt antibiotic …
emergent and elective surgery. Although early resuscitation efforts and prompt antibiotic …
Rare diseases and orphan products: Accelerating research and development
TF Boat, MJ Field - 2011 - books.google.com
Rare diseases collectively affect millions of Americans of all ages, but developing drugs and
medical devices to prevent, diagnose, and treat these conditions is challenging. The Institute …
medical devices to prevent, diagnose, and treat these conditions is challenging. The Institute …
Biological knowledge management: the emerging role of the Semantic Web technologies
E Antezana, M Kuiper, V Mironov - Briefings in bioinformatics, 2009 - academic.oup.com
New knowledge is produced at a continuously increasing speed, and the list of papers,
databases and other knowledge sources that a researcher in the life sciences needs to cope …
databases and other knowledge sources that a researcher in the life sciences needs to cope …
Sepsis: Something old, something new, and a systems view
Sepsis is a clinical syndrome characterized by a multisystem response to a microbial
pathogenic insult consisting of a mosaic of interconnected biochemical, cellular, and organ …
pathogenic insult consisting of a mosaic of interconnected biochemical, cellular, and organ …
A mechanistic insight into the mechanical role of the stratum corneum during stretching and compression of the skin
MF Leyva-Mendivil, A Page, NW Bressloff… - Journal of the Mechanical …, 2015 - Elsevier
The study of skin biophysics has largely been driven by consumer goods, biomedical and
cosmetic industries which aim to design products that efficiently interact with the skin and/or …
cosmetic industries which aim to design products that efficiently interact with the skin and/or …
Systems-based approaches toward wound healing
A Buganza Tepole, E Kuhl - Pediatric research, 2013 - nature.com
Wound healing in the pediatric patient is of utmost clinical and social importance because
hypertrophic scarring can have aesthetic and psychological sequelae, from early childhood …
hypertrophic scarring can have aesthetic and psychological sequelae, from early childhood …