Agent‐based models in translational systems biology

G An, Q Mi, J Dutta‐Moscato… - … : Systems Biology and …, 2009 - Wiley Online Library
Effective translational methodologies for knowledge representation are needed in order to
make strides against the constellation of diseases that affect the world today. These …

Systems medicine: the future of medical genomics and healthcare

C Auffray, Z Chen, L Hood - Genome medicine, 2009 - Springer
High-throughput technologies for DNA sequencing and for analyses of transcriptomes,
proteomes and metabolomes have provided the foundations for deciphering the structure …

Microphysiological engineering of self-assembled and perfusable microvascular beds for the production of vascularized three-dimensional human microtissues

J Paek, SE Park, Q Lu, KT Park, M Cho, JM Oh… - ACS …, 2019 - ACS Publications
The vasculature is an essential component of the circulatory system that plays a vital role in
the development, homeostasis, and disease of various organs in the human body. The …

Anti-inflammatory effect of vagus nerve stimulation in a rat model of inflammatory bowel disease

J Meregnani, D Clarençon, M Vivier… - Autonomic …, 2011 - Elsevier
Vagus nerve stimulation of afferents is used as an adjunctive treatment for drug-resistant
epilepsy and depression. In addition, anti-inflammatory properties of vagus nerve stimulation …

The shift of an intestinal “microbiome” to a “pathobiome” governs the course and outcome of sepsis following surgical injury

MA Krezalek, J DeFazio, O Zaborina, A Zaborin… - Shock, 2016 - journals.lww.com
Sepsis following surgical injury remains a growing and worrisome problem following both
emergent and elective surgery. Although early resuscitation efforts and prompt antibiotic …

Rare diseases and orphan products: Accelerating research and development

TF Boat, MJ Field - 2011 - books.google.com
Rare diseases collectively affect millions of Americans of all ages, but developing drugs and
medical devices to prevent, diagnose, and treat these conditions is challenging. The Institute …

Biological knowledge management: the emerging role of the Semantic Web technologies

E Antezana, M Kuiper, V Mironov - Briefings in bioinformatics, 2009 - academic.oup.com
New knowledge is produced at a continuously increasing speed, and the list of papers,
databases and other knowledge sources that a researcher in the life sciences needs to cope …

Sepsis: Something old, something new, and a systems view

R Namas, R Zamora, R Namas, G An, J Doyle… - Journal of critical …, 2012 - Elsevier
Sepsis is a clinical syndrome characterized by a multisystem response to a microbial
pathogenic insult consisting of a mosaic of interconnected biochemical, cellular, and organ …

A mechanistic insight into the mechanical role of the stratum corneum during stretching and compression of the skin

MF Leyva-Mendivil, A Page, NW Bressloff… - Journal of the Mechanical …, 2015 - Elsevier
The study of skin biophysics has largely been driven by consumer goods, biomedical and
cosmetic industries which aim to design products that efficiently interact with the skin and/or …

Systems-based approaches toward wound healing

A Buganza Tepole, E Kuhl - Pediatric research, 2013 - nature.com
Wound healing in the pediatric patient is of utmost clinical and social importance because
hypertrophic scarring can have aesthetic and psychological sequelae, from early childhood …