L-selectin (CD62L) is a type-I transmembrane glycoprotein and cell adhesion molecule that
is expressed on most circulating leukocytes. Since its identification in 1983, L-selectin has …

Sialic acids are a diverse family of monosaccharides widely expressed on all cell surfaces of
vertebrates and so‐called “higher” invertebrates, and on certain bacteria that interact with …

Human platelets arise as subcellular fragments of megakaryocytes in bone marrow. The
physiologic demand, presence of disease such as cancer, or drug effects can regulate the …

Reversible interactions of glycoconjugates on leukocytes with P-and E-selectin on
endothelial cells mediate tethering and rolling of leukocytes in inflamed vascular beds, the …

Cancer metastasis is facilitated by cell–cell interactions between cancer cells and
endothelial cells in distant tissues. In addition, cancer cell interactions with platelets and …

During the last decade, there have been enormous advances in our knowledge of
glycoproteins and the stage has been set for the biotechnological production of many of …

Vestweber, Dietmar, and James E. Blanks. Mechanisms That Regulate the Function of the
Selectins and Their Ligands. Physiol. Rev. 79: 181–213, 1999.—Selectins are a family of …

The circulatory and migratory properties of white blood cells have evolved to allow efficient
surveillance of tissues for infectious pathogens and rapid accu ญ mulation at sites of injury …

P selectin, expressed on surfaces of activated endothelial cells and platelets, is an adhesion
receptor for leukocytes. We report that P selectin-deficient mice, generated by gene targeting …

L-selectin, a cell adhesion molecule expressed by leukocytes, mediates the attachment of
lymphocytes to high endothelial venules (HEV) of peripheral lymph nodes and mediates the …