Human adenovirus gene expression and replication is regulated through dynamic changes in nucleoprotein structure throughout infection

MR Jennings, RJ Parks - Viruses, 2023 - mdpi.com
Human adenovirus (HAdV) is extremely common and can rapidly spread in confined
populations such as daycare centers, hospitals, and retirement homes. Although HAdV …

Epstein-Barr virus BNRF1 destabilizes SMC5/6 cohesin complexes to evade its restriction of replication compartments

SPT Yiu, R Guo, C Zerbe, MP Weekes, BE Gewurz - Cell reports, 2022 - cell.com
Epstein-Barr virus (EBV) persistently infects people worldwide. Delivery of∼ 170-kb EBV
genomes to nuclei and use of nuclear membrane-less replication compartments (RCs) for …

Novel viral splicing events and open reading frames revealed by long-read direct RNA sequencing of adenovirus transcripts

AM Price, RT Steinbock, R Lauman, M Charman… - PLoS …, 2022 - journals.plos.org
Adenovirus is a common human pathogen that relies on host cell processes for transcription
and processing of viral RNA and protein production. Although adenoviral promoters, splice …

[HTML][HTML] Proteomic analysis of antiviral innate immunity

JD Albarnaz, MP Weekes - Current Opinion in Virology, 2023 - Elsevier
Highlights•Antiviral innate immunity is regulated by changes in cellular proteins.•These
include changes in abundance, localisation, interaction and PTMs.•Viral immune evasion …

Phosphorylation regulates viral biomolecular condensates to promote infectious progeny production

N Grams, M Charman, E Halko, R Lauman… - The EMBO …, 2024 - embopress.org
Biomolecular condensates (BMCs) play important roles in diverse biological processes.
Many viruses form BMCs which have been implicated in various functions critical for the …

The protein composition of human adenovirus replication compartments

P Hidalgo, A Torres, PM Jean Beltran, G López-Leal… - mBio, 2024 - journals.asm.org
Human adenoviruses are double-stranded DNA viruses that replicate in the cell nucleus and
induce the formation of replication compartments (RCs) that are critical in viral replication …

Oncolytic virus: A catalyst for the treatment of gastric cancer

J Wang, L Du, X Chen - Frontiers in Oncology, 2022 - frontiersin.org
Gastric cancer (GC) is a leading contributor to global cancer incidence and mortality.
According to the GLOBOCAN 2020 estimates of incidence and mortality for 36 cancers in …

Identifying Protein Interactions with Viral DNA Genomes during Virus Infection

JE Packard, N Kumar, MD Weitzman, JA Dembowski - Viruses, 2024 - mdpi.com
Viruses exploit the host cell machinery to enable infection and propagation. This review
discusses the complex landscape of DNA virus–host interactions, focusing primarily on …

The heterogeneous sensitivity of pediatric brain tumors to different oncolytic viruses is predicted by unique gene expression profiles

K Vazaios, Ε Stavrakaki, LB Vogelezang, J Ju… - Molecular Therapy …, 2024 - cell.com
Despite decades of research, the prognosis of high-grade pediatric brain tumors (PBTs)
remains dismal; however, recent cases of favorable clinical responses were documented in …

Omics and systems view of innate immune pathways

D Rathore, MJ Marino, A Nita‐Lazar - Proteomics, 2023 - Wiley Online Library
Multiomics approaches to studying systems biology are very powerful techniques that can
elucidate changes in the genomic, transcriptomic, proteomic, and metabolomic levels within …