Obesity and heart failure with preserved ejection fraction (HFpEF) represent two
intermingling epidemics driving perhaps the greatest unmet health problem in …

Importance Antibody blockade of activin type II receptor (ActRII) signaling stimulates skeletal
muscle growth. Previous clinical studies suggest that ActRII inhibition with the monoclonal …

Heart failure is one of the main causes of morbidity and mortality around the globe. Heart
failure with preserved ejection fraction is primarily caused by diastolic dysfunction. Adipose …

Background: Obesity is strongly associated with exercise intolerance and the development
of heart failure. Whereas myocardial energetics and diastolic function are impaired in …

Background: Obesity may accelerate age-related increases in aortic stiffness. Although
aerobic exercise training generally has favorable effects on aortic structure and function …

Aims We sought to determine if myocardial energetics could distinguish obesity
cardiomyopathy as a distinct entity from dilated cardiomyopathy. Methods and results …

Preclinical data strongly suggest that myocardial steatosis leads to adverse cardiac
remodelling and left ventricular dysfunction. Using 1H cardiac magnetic resonance …

The objective of this study was to assess whether dietary-induced weight loss improves
myocardial deformation in people with overweight to obesity without established …

Aims To investigate the relationship between fibro‐inflammatory biomarkers and
cardiovascular structure/function in people with Type 2 Diabetes (T2D) compared to healthy …

Background Obesity is a well-known risk factor for heart disease, resulting in a broad
spectrum of cardiovascular changes. Left ventricular mass (LVM) and contractility are …