The quest to slow ageing through drug discovery

L Partridge, M Fuentealba, BK Kennedy - Nature Reviews Drug …, 2020 - nature.com
Although death is inevitable, individuals have long sought to alter the course of the ageing
process. Indeed, ageing has proved to be modifiable; by intervening in biological systems …

Effect of glucosamine and chondroitin sulfate in symptomatic knee osteoarthritis: a systematic review and meta-analysis of randomized placebo-controlled trials

M Simental-Mendia, A Sanchez-Garcia… - Rheumatology …, 2018 - Springer
Although glucosamine and chondroitin sulfate have showed beneficial effects on joint
tissues in osteoarthritis (OA), their therapeutic use in the clinical setting is still debatable …

Antimicrobial and antiviral activities of durable cotton fabrics treated with nanocomposite based on zinc oxide nanoparticles, acyclovir, nanochitosan, and clove oil

AM Shehabeldine, AH Hashem, AR Wassel… - Applied biochemistry …, 2022 - Springer
In this study, cotton fabrics based on zinc oxide nanoparticles in situ synthesis, acyclovir,
nanochitosan, and clove oil were treated. The treated cotton fabrics were examined by FTIR …

The Warburg effect and glucose-derived cancer theranostics

RK Tekade, X Sun - Drug Discovery Today, 2017 - Elsevier
Highlights•Tumor cells increase their metabolic rates as well as glucose uptake to maintain
amplified proliferation,•Consequently, tumor cells switch from mitochondrial oxidative …

A Broad-Specificity Chitinase from Penicillium oxalicum k10 Exhibits Antifungal Activity and Biodegradation Properties of Chitin

XH Xie, X Fu, XY Yan, WF Peng, LX Kang - Marine Drugs, 2021 - mdpi.com
Penicillium oxalicum k10 isolated from soil revealed the hydrolyzing ability of shrimp chitin
and antifungal activity against Sclerotinia sclerotiorum. The k10 chitinase was produced …

Molecular mechanisms of anticancer effects of Glucosamine

F Zahedipour, R Dalirfardouei, G Karimi… - Biomedicine & …, 2017 - Elsevier
Glucosamine is an amino sugar that is produced naturally in human body. It is an essential
carbohydrate component of many cellular glycoproteins, glycolipids, and …

Artificial in vitro synthetic enzymatic biosystem for the one-pot sustainable biomanufacturing of glucosamine from starch and inorganic ammonia

D Meng, X Wei, X Bai, W Zhou, C You - Acs Catalysis, 2020 - ACS Publications
Glucosamine is a naturally occurring bioactive amino monosaccharide which is widely used
in the food, cosmetics, and pharmaceutical industries. It is traditionally produced by acid …

Effect of saccharides coating on antibacterial potential and drug loading and releasing capability of plasma treated polylactic acid films

I Karakurt, K Ozaltin, H Pištěková, D Vesela… - International Journal of …, 2022 - mdpi.com
More than half of the hospital-associated infections worldwide are related to the adhesion of
bacteria cells to biomedical devices and implants. To prevent these infections, it is crucial to …

Computational assessment of the pharmacological profiles of degradation products of chitosan

DL Roman, M Roman, C Som, M Schmutz… - … in bioengineering and …, 2019 - frontiersin.org
Chitosan is a natural polymer revealing an increased potential to be used in different
biomedical applications, including drug delivery systems, and tissue engineering. It implies …

Dual function of glucosamine in gelatin/hyaluronic acid cryogel to modulate scaffold mechanical properties and to maintain chondrogenic phenotype for cartilage …

CH Chen, CY Kuo, YJ Wang, JP Chen - International Journal of …, 2016 - mdpi.com
Glucosamine (GlcN) fulfills many of the requirements as an ideal component in scaffolds
used in cartilage tissue engineering. The incorporation of GlcN in a gelatin/hyaluronic acid …