Protein kinase C (PKC) has been a tantalizing target for drug discovery ever since it was first
identified as the receptor for the tumour promoter phorbol ester in 1982. Although initial …

The AGC family of serine/threonine kinases (PKA, PKG, PKC) includes more than 60
members that are critical regulators of numerous cellular functions, including cell cycle and …

It is now becoming apparent that dynamic changes occur within the interstitium that directly
contribute to adverse myocardial remodeling following myocardial infarction (MI), with …

The process by which extracellular signals are relayed from the plasma membrane to
specific intracellular sites is an essential facet of cellular regulation. Many signaling …

The protein kinase C family of enzymes transduces the myriad of signals promoting lipid
hydrolysis. The prevalence of this enzyme family in signaling is exemplified by the diverse …

The yeast cell wall is a highly dynamic structure that is responsible for protecting the cell
from rapid changes in external osmotic potential. The wall is also critical for cell expansion …

Plants exhibit a variety of responses to abiotic stresses that enable them to tolerate and
survive adverse conditions. As we learn more about the signalling pathways leading to …

Members of the mammalian protein kinase C (PKC) superfamily play key regulatory roles in
a multitude of cellular processes, ranging from control of fundamental cell autonomous …

Environmental stresses converge on the mitochondria that can trigger or inhibit cell death.
Excitable, postmitotic cells, in response to sublethal noxious stress, engage mechanisms …

Mitogen-activated protein kinases (MAPKs) are components of a three kinase regulatory
cascade. There are multiple members of each component family of kinases in the MAPK …