The absolute reliance of the mammalian brain on oxygen to generate ATP renders it acutely
vulnerable to hypoxia, whether at high altitude or in clinical settings of anemia or pulmonary …

During acute episodes of hypoxia, chemoreceptor-mediated sympathetic activity increases
heart rate, cardiac output, peripheral resistance and systemic arterial pressure. However …

Mitochondrial oxidative damage is a basic mechanism of aging, and multiple studies
demonstrate that this process is attenuated by calorie restriction (CR). However, the …

The global industrialization has brought profound lifestyle changes and environmental
pollutions leading to higher risks of cardiovascular diseases. Such tremendous challenges …

Sex differences in physiological responses to various stressors, including exercise, have
been well documented. However, the specific impact of these differences on exposure to …

ABSTRACT Shatilo, Valeriy B., Oleg V. Korkushko, Vadim A. Ischuk, H. Fred Downey, and
Tatiana V. Serebrovskaya. Effects of intermittent hypoxia training on exercise performance …

Abstract Richalet, Jean-Paul, and François J. Lhuissier. Aging, tolerance to high altitude,
and cardiorespiratory response to hypoxia. High Alt Med Biol. 16: 117–124, 2015.—It is …

Acute and chronic exposure to high altitude induces various physiological changes,
including activation or inhibition of various hormonal systems. In response to activation …

This pre-eminent work has developed over six editions in response to man's attempts to
climb higher and higher unaided, and to spend more time at altitude for both work and …

Key points• A previous study showed that an older age could be associated with a lower risk
of severe altitude‐induced diseases.• This work combines a cross‐sectional study including …