Experimental autoimmune encephalomyelitis (EAE) as a model for multiple sclerosis (MS)
CS Constantinescu, N Farooqi… - British journal of …, 2011 - Wiley Online Library
Experimental autoimmune encephalomyelitis (EAE) is the most commonly used
experimental model for the human inflammatory demyelinating disease, multiple sclerosis …
experimental model for the human inflammatory demyelinating disease, multiple sclerosis …
Pyrrole: An insight into recent pharmacological advances with structure activity relationship
Pyrrole is a heterocyclic ring template with multiple pharmacophores that provides a way for
the generation of library of enormous lead molecules. Owing to its vast pharmacological …
the generation of library of enormous lead molecules. Owing to its vast pharmacological …
Role of microglia in neurological disorders and their potentials as a therapeutic target
L Du, Y Zhang, Y Chen, J Zhu, Y Yang… - Molecular neurobiology, 2017 - Springer
Microglia are resident macrophage-like immune cells in the central nervous system (CNS)
and play a vital role in both physiological and pathological conditions, including restoring …
and play a vital role in both physiological and pathological conditions, including restoring …
Integrating endocannabinoid signaling and cannabinoids into the biology and treatment of posttraumatic stress disorder
Exposure to stress is an undeniable, but in most cases surmountable, part of life. However,
in certain individuals, exposure to severe or cumulative stressors can lead to an array of …
in certain individuals, exposure to severe or cumulative stressors can lead to an array of …
Modulating the endocannabinoid system in human health and disease–successes and failures
The discovery of the endocannabinoid system, comprising the G‐protein coupled
cannabinoid 1 and 2 receptors (CB 1/2), their endogenous lipid ligands or …
cannabinoid 1 and 2 receptors (CB 1/2), their endogenous lipid ligands or …
Cannabinoids as novel anti-inflammatory drugs
P Nagarkatti, R Pandey, SA Rieder… - Future medicinal …, 2009 - Taylor & Francis
Cannabinoids are a group of compounds that mediate their effects through cannabinoid
receptors. The discovery of Δ9-tetrahydrocannabinol (THC) as the major psychoactive …
receptors. The discovery of Δ9-tetrahydrocannabinol (THC) as the major psychoactive …
Is lipid signaling through cannabinoid 2 receptors part of a protective system?
P Pacher, R Mechoulam - Progress in lipid research, 2011 - Elsevier
The mammalian body has a highly developed immune system which guards against
continuous invading protein attacks and aims at preventing, attenuating or repairing the …
continuous invading protein attacks and aims at preventing, attenuating or repairing the …
Cannabinoid receptor signaling in progenitor/stem cell proliferation and differentiation
I Galve-Roperh, V Chiurchiù, J Díaz-Alonso… - Progress in lipid …, 2013 - Elsevier
Cannabinoids, the active components of cannabis (Cannabis sativa) extracts, have attracted
the attention of human civilizations for centuries, much earlier than the discovery and …
the attention of human civilizations for centuries, much earlier than the discovery and …
New insights and potential therapeutic targeting of CB2 cannabinoid receptors in CNS disorders
The endocannabinoid system (ECS) is ubiquitous in most human tissues, and involved in
the regulation of mental health. Consequently, its dysregulation is associated with …
the regulation of mental health. Consequently, its dysregulation is associated with …
Cannabinoid Type 2 (CB2) Receptors Activation Protects against Oxidative Stress and Neuroinflammation Associated Dopaminergic Neurodegeneration in Rotenone …
The cannabinoid type two receptors (CB2), an important component of the endocannabinoid
system, have recently emerged as neuromodulators and therapeutic targets for …
system, have recently emerged as neuromodulators and therapeutic targets for …