[HTML][HTML] Chondrosarcoma: a rare misfortune in aging human cartilage? The role of stem and progenitor cells in proliferation, malignant degeneration and therapeutic …
Unlike other malignant bone tumors including osteosarcomas and Ewing sarcomas with a
peak incidence in adolescents and young adults, conventional and dedifferentiated …
peak incidence in adolescents and young adults, conventional and dedifferentiated …
[HTML][HTML] Genetics of osteoarthritis
G Zhai, J Huang - Best Practice & Research Clinical Rheumatology, 2024 - Elsevier
Osteoarthritis (OA) is the most common form of arthritis with well recognized multifactorial
nature. While several environmental factors such as older age, obesity and previous joint …
nature. While several environmental factors such as older age, obesity and previous joint …
[HTML][HTML] Comparison of the major cell populations among osteoarthritis, Kashin–Beck disease and healthy chondrocytes by single-cell RNA-seq analysis
X Wang, Y Ning, P Zhang, B Poulet, R Huang… - Cell death & …, 2021 - nature.com
Chondrocytes are the key target cells of the cartilage degeneration that occurs in Kashin–
Beck disease (KBD) and osteoarthritis (OA). However, the heterogeneity of articular cartilage …
Beck disease (KBD) and osteoarthritis (OA). However, the heterogeneity of articular cartilage …
[HTML][HTML] Osteoarthritis year in review 2018: genetics and epigenetics
MA Jeffries - Osteoarthritis and cartilage, 2019 - Elsevier
Objective This review was designed to identify highlights of the osteoarthritis (OA) genetics
and epigenetics literature published between April 2017 and January 2018. Design A …
and epigenetics literature published between April 2017 and January 2018. Design A …
[HTML][HTML] Osteoarthritis year in review 2017: genetics and epigenetics
MJ Peffers, P Balaskas, A Smagul - Osteoarthritis and cartilage, 2018 - Elsevier
Objective The purpose of this review is to describe highlights from original research
publications related to osteoarthritis (OA), epigenetics and genomics with the intention of …
publications related to osteoarthritis (OA), epigenetics and genomics with the intention of …
[HTML][HTML] Cathelicidin antimicrobial peptide (CAMP) gene promoter methylation induces chondrocyte apoptosis
G Wang, Y Li, G Yang, T Yang, L He, Y Wang - Human Genomics, 2021 - Springer
Objective The occurrence of osteoarthritis is related to genetic and environmental factors.
Among them, the change of chondrocyte gene expression pattern regulated by epigenetic …
Among them, the change of chondrocyte gene expression pattern regulated by epigenetic …
[HTML][HTML] Epigenetics as a therapeutic target in osteoarthritis
C Núñez-Carro, M Blanco-Blanco… - Pharmaceuticals, 2023 - mdpi.com
Osteoarthritis (OA) is a heterogenous, complex disease affecting the integrity of diarthrodial
joints that, despite its high prevalence worldwide, lacks effective treatment. In recent years it …
joints that, despite its high prevalence worldwide, lacks effective treatment. In recent years it …
[HTML][HTML] Aberrant methylation and expression of TNXB promote chondrocyte apoptosis and extracullar matrix degradation in hemophilic arthropathy via AKT signaling
J Chen, Q Zeng, X Wang, R Xu, W Wang, Y Huang… - Elife, 2024 - elifesciences.org
Recurrent joint bleeding in hemophilia patients frequently causes hemophilic arthropathy
(HA). Drastic degradation of cartilage is a major characteristic of HA, but its pathological …
(HA). Drastic degradation of cartilage is a major characteristic of HA, but its pathological …
[HTML][HTML] Genome-Wide Differentially Methylated Region Analysis to Reveal Epigenetic Differences of Articular Cartilage in Kashin–Beck Disease and Osteoarthritis
Y Fan, D Gao, Y Zhang, J Zhu, F Zhang… - Frontiers in Cell and …, 2021 - frontiersin.org
Kashin–Beck disease (KBD) is a degenerative osteoarticular disorder, and displays the
significant differences with osteoarthritis (OA) regarding the etiology and molecular changes …
significant differences with osteoarthritis (OA) regarding the etiology and molecular changes …
[HTML][HTML] Identification of candidate genes and chemicals associated with osteonecrosis of femoral head by multiomics studies and chemical-gene interaction analysis
X Lu, X Wang, P Wang, Y Zhu, J Liu, G Liu… - Frontiers in …, 2024 - frontiersin.org
Objectives In-depth understanding of osteonecrosis of femoral head (ONFH) has revealed
that degeneration of the hip cartilage plays a crucial role in ONFH progression. However, the …
that degeneration of the hip cartilage plays a crucial role in ONFH progression. However, the …