Ethnobotany and the role of plant natural products in antibiotic drug discovery

G Porras, F Chassagne, JT Lyles, L Marquez… - Chemical …, 2020 - ACS Publications
The crisis of antibiotic resistance necessitates creative and innovative approaches, from
chemical identification and analysis to the assessment of bioactivity. Plant natural products …

[HTML][HTML] Version updates of strategies for drug discovery based on effective constituents of traditional Chinese medicine

N Ge, G Yan, H Sun, L Yang, L Kong… - … and Herbal Medicine, 2023 - journals.lww.com
The discovery of effective constituents of traditional Chinese medicine (TCM) is an important
approach in new drug development. Several well-known drugs, such as artemisinin …

Interaction metabolomics to discover synergists in natural product mixtures

WS Vidar, TUH Baumeister, LK Caesar… - Journal of Natural …, 2023 - ACS Publications
Mass spectrometry metabolomics has become increasingly popular as an integral aspect of
studies to identify active compounds from natural product mixtures. Classical metabolomics …

Efficacy and safety of the traditional herbal medication Chai-Ling-Tang (in China), Siryung-tang (in Republic of Korea) or Sairei-To (in Japan)

C Bailly - Journal of ethnopharmacology, 2023 - Elsevier
Ethnopharmacological relevance The herbal medicine designated Chai-Ling-Tang in China,
Siryung-tang in South Korea, and Sairei-To (or Tsumura Saireito extract granules, TJ-114) in …

Castaneroxy A From the Leaves of Castanea sativa Inhibits Virulence in Staphylococcus aureus

AM Salam, G Porras, YSK Cho, MM Brown… - Frontiers in …, 2021 - frontiersin.org
Methicillin-resistant Staphylococcus aureus (MRSA) represents one of the most serious
infectious disease concerns worldwide, with the CDC labeling it a “serious threat” in 2019 …

Aqueous Extract of Artemisia annua Shows In Vitro Antimicrobial Activity and an In Vivo Chemopreventive Effect in a Small-Cell Lung Cancer Model

KS Allemailem - Plants, 2022 - mdpi.com
Artemisia annua (A. annua) has been used as a medicinal plant in the treatment of several
infectious and non-infectious diseases in the forms of tea and press juice since ancient …

Pentagalloyl glucose from Schinus terebinthifolia inhibits growth of carbapenem-resistant Acinetobacter baumannii

M Dettweiler, L Marquez, M Lin, AM Sweeney-Jones… - Scientific reports, 2020 - nature.com
The rise of antibiotic resistance has necessitated a search for new antimicrobials with potent
activity against multidrug-resistant gram-negative pathogens, such as carbapenem-resistant …

Δ9-Tetrahydrocannabinol Differentially Alters Cannabidiol Efficacy in Recovery of Phonology and Syntax Following Damage to a Songbird Cortical-Like Brain Region

RM Hodges, KJ Chase, MA Tripson… - Cannabis and …, 2023 - liebertpub.com
Introduction: There are few vocal learning animals that are suitable for laboratory study, and
so songbirds have unique utility for evaluating drug effects on behavior learned during a …

A Chemical Investigation of the Antioxidant Capacity of Extracts from Red Macroalga Gracilaria domingensis

P Torres, F Chow, DYAC dos Santos - Phycology, 2022 - mdpi.com
Extracts that were obtained with solvents of increasing polarity (hexane, dichloromethane,
methanol, 80% methanol, and water) from the red macroalga Gracilaria domingensis were …

Antiplasmodial and antimycobacterial activities of crude and lead-like enhanced extracts from Namibian medicinal plants

C Raidron, A Jordaan, R Seldon, DF Warner… - Journal of …, 2022 - Elsevier
Ethnopharmacological relevance Eight indigenous medicinal plants which are used
traditionally for the treatment of tuberculosis (TB), malaria, and associated symptoms, were …