Liver transplantation has become an immense success; nevertheless, far more recipients
are registered on waiting lists than there are available donor livers for transplantation. High …

End-stage liver disease patients undergoing liver transplantation are prone to develop
numerous infectious complications because of immunosuppression, surgical interventions …

Although short‐term machine perfusion (≤ 24 h) allows for resuscitation and viability
assessment of high‐risk donor livers, the donor organ shortage might be further remedied by …

Currently, two distinguished ways of preserving the graft before implantation exist:
hypothermic conditions lead to metabolic suppression, whereas normothermic perfusion …

Background. Normothermic machine perfusion (NMP) is used to preserve and test donor
livers before transplantation. During NMP, the liver is metabolically active and produces …

Background Ex situliver machine perfusion at subnormothermic/normothermic temperature
isincreasingly applied in the field of transplantation to store and evaluateorgans on the …

Robust viability assessment of grafts during normothermic liver perfusion is a prerequisite for
organ use. Coagulation parameters are used commonly for liver assessment in patients …

Metabolic and toxic liver disorders, such as fatty liver disease (steatosis) and drug-induced
liver injury, are highly prevalent and potentially life-threatening. To allow for the study of …

Background. Normothermic machine perfusion permits the ex vivo preservation of human
livers before transplantation. Long-term perfusion for days-to-weeks provides the opportunity …

Preservation techniques that maintain the viability of an organ graft between retrieval from
the donor and implantation into the recipient remain a critical aspect of solid organ …