Emerging digital PCR technology in precision medicine
L Zhang, R Parvin, Q Fan, F Ye - Biosensors and Bioelectronics, 2022 - Elsevier
Digital PCR (dPCR) is built on partitioning reagent to the extent that single template
molecules are amplified and visualized individually, whereby offers higher precision and …
molecules are amplified and visualized individually, whereby offers higher precision and …
[HTML][HTML] Peptide drug conjugates and their role in cancer therapy
E Heh, J Allen, F Ramirez, D Lovasz… - International Journal of …, 2023 - mdpi.com
Drug conjugates have become a significant focus of research in the field of targeted
medicine for cancer treatments. Peptide-drug conjugates (PDCs), a subset of drug …
medicine for cancer treatments. Peptide-drug conjugates (PDCs), a subset of drug …
[HTML][HTML] Taking the Myc out of cancer: toward therapeutic strategies to directly inhibit c-Myc
Abstract c-Myc is a transcription factor that is constitutively and aberrantly expressed in over
70% of human cancers. Its direct inhibition has been shown to trigger rapid tumor regression …
70% of human cancers. Its direct inhibition has been shown to trigger rapid tumor regression …
[HTML][HTML] Recent advances on bioactive food derived anti-diabetic hydrolysates and peptides from natural resources
E Elam, J Feng, YM Lv, ZJ Ni, P Sun, K Thakur… - Journal of functional …, 2021 - Elsevier
In recent years, burgeoning reports have emphasized that food-derived peptides and protein
hydrolysates can confer additional health benefits beyond nutritional role. The biologically …
hydrolysates can confer additional health benefits beyond nutritional role. The biologically …
Targeted therapy for osteosarcoma: a review
S Li, H Zhang, J Liu, G Shang - Journal of cancer research and clinical …, 2023 - Springer
Background Osteosarcoma is a common primary malignant tumour of the bone that usually
occurs in children and adolescents. It is characterised by difficult treatment, recurrence and …
occurs in children and adolescents. It is characterised by difficult treatment, recurrence and …
[HTML][HTML] 3D tumor spheroid microarray for high-throughput, high-content natural killer cell-mediated cytotoxicity
Immunotherapy has emerged as a promising approach to treating several forms of cancer.
Use of immune cells, such as natural killer (NK) cells, along with small molecule drugs and …
Use of immune cells, such as natural killer (NK) cells, along with small molecule drugs and …
[HTML][HTML] In silico Approaches for the Design and Optimization of Interfering Peptides Against Protein–Protein Interactions
Large contact surfaces of protein–protein interactions (PPIs) remain to be an ongoing issue
in the discovery and design of small molecule modulators. Peptides are intrinsically capable …
in the discovery and design of small molecule modulators. Peptides are intrinsically capable …
[HTML][HTML] It's getting complicated—a fresh look at p53-MDM2-ARF triangle in tumorigenesis and cancer therapy
Anti-tumorigenic mechanisms mediated by the tumor suppressor p53, upon oncogenic
stresses, are our bodies' greatest weapons to battle against cancer onset and development …
stresses, are our bodies' greatest weapons to battle against cancer onset and development …
[HTML][HTML] The androgen receptor/filamin A complex as a target in prostate cancer microenvironment
M Di Donato, A Zamagni, G Galasso, E Di Zazzo… - Cell Death & …, 2021 - nature.com
Prostate cancer represents the major cause of cancer-related death in men and patients
frequently develop drug-resistance and metastatic disease. Most studies focus on hormone …
frequently develop drug-resistance and metastatic disease. Most studies focus on hormone …
[HTML][HTML] Rab GTPases: emerging oncogenes and tumor suppressive regulators for the editing of survival pathways in cancer
PD Gopal Krishnan, E Golden, EA Woodward… - Cancers, 2020 - mdpi.com
The Rab GTPase family of proteins are mediators of membrane trafficking, conferring identity
to the cell membranes. Recently, Rab and Rab-associated factors have been recognized as …
to the cell membranes. Recently, Rab and Rab-associated factors have been recognized as …