Emerging digital PCR technology in precision medicine

L Zhang, R Parvin, Q Fan, F Ye - Biosensors and Bioelectronics, 2022 - Elsevier
Digital PCR (dPCR) is built on partitioning reagent to the extent that single template
molecules are amplified and visualized individually, whereby offers higher precision and …

[HTML][HTML] Peptide drug conjugates and their role in cancer therapy

E Heh, J Allen, F Ramirez, D Lovasz… - International Journal of …, 2023 - mdpi.com
Drug conjugates have become a significant focus of research in the field of targeted
medicine for cancer treatments. Peptide-drug conjugates (PDCs), a subset of drug …

[HTML][HTML] Taking the Myc out of cancer: toward therapeutic strategies to directly inhibit c-Myc

SK Madden, AD de Araujo, M Gerhardt, DP Fairlie… - Molecular Cancer, 2021 - Springer
Abstract c-Myc is a transcription factor that is constitutively and aberrantly expressed in over
70% of human cancers. Its direct inhibition has been shown to trigger rapid tumor regression …

[HTML][HTML] Recent advances on bioactive food derived anti-diabetic hydrolysates and peptides from natural resources

E Elam, J Feng, YM Lv, ZJ Ni, P Sun, K Thakur… - Journal of functional …, 2021 - Elsevier
In recent years, burgeoning reports have emphasized that food-derived peptides and protein
hydrolysates can confer additional health benefits beyond nutritional role. The biologically …

Targeted therapy for osteosarcoma: a review

S Li, H Zhang, J Liu, G Shang - Journal of cancer research and clinical …, 2023 - Springer
Background Osteosarcoma is a common primary malignant tumour of the bone that usually
occurs in children and adolescents. It is characterised by difficult treatment, recurrence and …

[HTML][HTML] 3D tumor spheroid microarray for high-throughput, high-content natural killer cell-mediated cytotoxicity

S Gopal, SJ Kwon, B Ku, DW Lee, J Kim… - Communications …, 2021 - nature.com
Immunotherapy has emerged as a promising approach to treating several forms of cancer.
Use of immune cells, such as natural killer (NK) cells, along with small molecule drugs and …

[HTML][HTML] In silico Approaches for the Design and Optimization of Interfering Peptides Against Protein–Protein Interactions

ZS Hashemi, M Zarei, MK Fath, M Ganji… - Frontiers in Molecular …, 2021 - frontiersin.org
Large contact surfaces of protein–protein interactions (PPIs) remain to be an ongoing issue
in the discovery and design of small molecule modulators. Peptides are intrinsically capable …

[HTML][HTML] It's getting complicated—a fresh look at p53-MDM2-ARF triangle in tumorigenesis and cancer therapy

CP Kung, JD Weber - Frontiers in cell and developmental biology, 2022 - frontiersin.org
Anti-tumorigenic mechanisms mediated by the tumor suppressor p53, upon oncogenic
stresses, are our bodies' greatest weapons to battle against cancer onset and development …

[HTML][HTML] The androgen receptor/filamin A complex as a target in prostate cancer microenvironment

M Di Donato, A Zamagni, G Galasso, E Di Zazzo… - Cell Death & …, 2021 - nature.com
Prostate cancer represents the major cause of cancer-related death in men and patients
frequently develop drug-resistance and metastatic disease. Most studies focus on hormone …

[HTML][HTML] Rab GTPases: emerging oncogenes and tumor suppressive regulators for the editing of survival pathways in cancer

PD Gopal Krishnan, E Golden, EA Woodward… - Cancers, 2020 - mdpi.com
The Rab GTPase family of proteins are mediators of membrane trafficking, conferring identity
to the cell membranes. Recently, Rab and Rab-associated factors have been recognized as …