Mechanical signalling affects multiple biological processes during development and in adult
organisms, including cell fate transitions, cell migration, morphogenesis and immune …

Focal adhesion kinase (FAK), a non-receptor tyrosine kinase, is overexpressed and
activated in many cancer types. FAK regulates diverse cellular processes, including growth …

Focal adhesion kinase (FAK) is a cytoplasmic protein tyrosine kinase that is overexpressed
and activated in several advanced-stage solid cancers. FAK promotes tumour progression …

Focal adhesion kinase (FAK) is a key regulator of growth factor receptor-and integrin-
mediated signals, governing fundamental processes in normal and cancer cells through its …

FAK is a tyrosine kinase overexpressed in cancer cells and plays an important role in the
progression of tumors to a malignant phenotype. Except for its typical role as a cytoplasmic …

Integrin adhesion complexes (IACs) are integrin-based plasma-membrane-associated
compartments where cells sense environmental cues. The physical mechanisms and …

Focal adhesion kinase (FAK) is a non-receptor tyrosine kinase with key roles in the
regulation of cell adhesion migration, proliferation and survival. In cancer FAK is a major …

Highlights•FAK undergoes conformational activation and dimerization.•FAK activation can
occur at adhesions, on endosomes, and in the nucleus.•FAK localizes to adherens junctions …

Focal adhesion kinase (FAK), a nonreceptor cytoplasmic tyrosine kinase, is a vital
participant in primary cellular functions, such as proliferation, survival, migration, and …

Focal adhesion kinase (FAK; also known as PTK2) was discovered three decades ago and
is now recognised as a key player in the regulation of cell–matrix adhesion and …