Charged and polar groups, through forming ion pairs, hydrogen bonds, and other less
specific electrostatic interactions, impart important properties to proteins. Modulation of the …

Spleen tyrosine kinase (SYK) is known to have a crucial role in adaptive immune receptor
signalling. However, recent reports indicate that SYK also mediates other, unexpectedly …

SH2 domains are interaction modules uniquely dedicated to the recognition of
phosphotyrosine sites and are embedded in proteins that couple protein-tyrosine kinases to …

Recruitment of leucocytes such as neutrophils to the extravascular space is a critical step of
the inflammation process and plays a major role in the development of various diseases …

Phosphoinositide-specific phospholipase C (PLC) enzymes are common signalling
components linked to the activation of most cellular receptors. All PLC families are complex …

The B cell receptor (BCR) transduces antigen binding into alterations in the activity of
intracellular signaling pathways through its ability to recruit and activate the cytoplasmic …

Direct activation of the human phospholipase C-γ isozymes (PLC-γ1,-γ2) by tyrosine
phosphorylation is fundamental to the control of diverse biological processes, including …

SH2 domain-mediated interactions represent a crucial step in transmembrane signaling by
receptor tyrosine kinases. SH2 domains recognize phosphotyrosine (pY) in the context of …

The insulin signaling pathway is critical in regulating glucose levels and is associated with
diabetes, obesity, and longevity. A tyrosine phosphorylation cascade creates docking sites …

SH2 (Src Homology 2) domains are among the best characterized and most studied protein-
protein interaction (PPIs) modules able to bind and recognize sequences presenting a …