Today, RNA aptamers are being considered promising theranostic tools against a wide
variety of disorders. RNA aptamers can fold into complex shapes and bind to diverse …

Aptamers are single-stranded DNA or RNA oligomers, identified from a random sequence
pool, with the ability to form unique and versatile tertiary structures that bind to cognate …

Bone marrow mesenchymal stem cells (BMSCs) exhibit an age-dependent reduction in
osteogenesis that is accompanied by an increased propensity toward adipocyte …

Insulin resistance is the major pathological characteristic of type 2 diabetes, and the elderly
often develop insulin resistance. However, the deep-seated mechanisms for aging-related …

A specific bone vessel subtype, strongly positive for CD31 and endomucin (CD31hiEmcnhi),
is identified as coupling angiogenesis and osteogenesis. The abundance of type …

Biomarkers are detectable molecules that can reflect specific physiological states of cells,
organs, and organisms and therefore be regarded as indicators for specific diseases. And …

The discovery and identification of biomarkers promote the rational and fast development of
medical diagnosis and therapeutics. Clinically, the application of ideal biomarkers still is …

Biomarker discovery is essential for the understanding, diagnosis, targeted therapy and
prognosis assessment of malignant diseases. However, it remains a huge challenge due to …

The recent SARS-CoV-2 outbreak has been declared a global health emergency. It will take
years to vaccinate the whole population to protect them from this deadly virus, hence the …

Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy that is
characterized by early metastasis, low resectability, high recurrence, and therapy resistance …